The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity.

The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity.

Item
http://www.wikidata.org/entity/Q34623161
Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeysIn vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeysNociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.Orphan GPCR research.Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway.Development of nociceptin receptor (NOP) agonists and antagonists.Recently patented and promising ORL-1 ligands: where have we been and where are we going?UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor.Neuropeptides: metabolism to bioactive fragments and the pharmacology of their receptors.Cebranopadol: novel dual opioid/NOP receptor agonist analgesic.Targeting multiple opioid receptors - improved analgesics with reduced side effects?In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands.Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198)Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair.
P2860

The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity.

Item
http://www.wikidata.org/entity/Q34623161
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年論文
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2007年論文
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2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
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name
The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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type
label
The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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prefLabel
The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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The pharmacology of Ro 64-6198 ...... clinical therapeutic activity.
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P2093
P2860
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P356
10.1111/J.1527-3458.2007.00007.X
P433
P478
P50
P577
P5875
P698
P921
P932