Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene - Wikidata - awgldk - TriplyDB

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

http://www.wikidata.org/entity/Q28349476

about

Main roads to melanoma COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ Kinetic mechanism of AKT/PKB enzyme family VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase Identification of a proline-rich Akt substrate as a 14-3-3 binding partner Essential role of PDK1 in regulating cell size and development in mice Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage A mosaic activating mutation in AKT1 associated with the Proteus syndrome Therapeutic Implications of Targeting AKT Signaling in Melanoma Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies Akt1 in endothelial cell and angiogenesis FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway Medical treatment for gastro-entero-pancreatic neuroendocrine tumours Connecting Myokines and Metabolism Akt isoforms in vascular disease PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy mTOR-dependent cell survival mechanisms Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging Molecular basis of physiological heart growth: fundamental concepts and new players Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma Posttranslational regulation of Akt in human cancer Park7 expression influences myotube size and myosin expression in muscle The hemodynamic basis for positional- and inter-fetal dependent effects in dual arterial supply of mouse pregnancies Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells PTEN is a protein tyrosine phosphatase for IRS1 mTOR signaling in tumorigenesis Haploinsufficiency of akt1 prolongs the lifespan of mice Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity PI3K/PTEN signaling in angiogenesis and tumorigenesis Role for Akt3/protein kinase Bgamma in attainment of normal brain size Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells Possible molecular mechanisms underlying age-related cardiomyocyte apoptosis in the F344XBN rat heart

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P2860

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

http://www.wikidata.org/entity/Q28349476

description

2001 nî lūn-bûn

@nan

2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

name

Growth retardation and increas ...... us disruption of the Akt1 gene

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Growth retardation and increas ...... us disruption of the Akt1 gene

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Growth retardation and increas ...... us disruption of the Akt1 gene

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type

label

Growth retardation and increas ...... us disruption of the Akt1 gene

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Growth retardation and increas ...... us disruption of the Akt1 gene

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Growth retardation and increas ...... us disruption of the Akt1 gene

@nl

prefLabel

Growth retardation and increas ...... us disruption of the Akt1 gene

@ast

Growth retardation and increas ...... us disruption of the Akt1 gene

@en

Growth retardation and increas ...... us disruption of the Akt1 gene

@nl

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Genes & Development

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Growth retardation and increas ...... us disruption of the Akt1 gene

@en

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I Roninson

http://www.w3.org/2001/XMLSchema#string

K Gottlob

http://www.w3.org/2001/XMLSchema#string

K Sokol

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K Tobe

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M L Chen

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N Hay

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P Z Xu

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R Suzuki

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T Kadowaki

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T Shiyanova

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P2860

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

PTEN: life as a tumor suppressor

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

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2203-8

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scholarly article

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1637185

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10.1101/GAD.913901

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17

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15

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11802634

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11544177

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apoptotic process

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312770

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