Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo
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Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug DiscoveryIncreased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide.Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels.Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential.
P2860
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo
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2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
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name
Increased rigidity of the chir ...... antimyotonic activity in vivo
@ast
Increased rigidity of the chir ...... antimyotonic activity in vivo
@en
Increased rigidity of the chir ...... antimyotonic activity in vivo
@nl
type
label
Increased rigidity of the chir ...... antimyotonic activity in vivo
@ast
Increased rigidity of the chir ...... antimyotonic activity in vivo
@en
Increased rigidity of the chir ...... antimyotonic activity in vivo
@nl
prefLabel
Increased rigidity of the chir ...... antimyotonic activity in vivo
@ast
Increased rigidity of the chir ...... antimyotonic activity in vivo
@en
Increased rigidity of the chir ...... antimyotonic activity in vivo
@nl
P2093
P2860
P50
P3181
P356
P1476
Increased rigidity of the chir ...... antimyotonic activity in vivo
@en
P2093
A Scilimati
D Conte Camerino
H Jockusch
J F Desaphy
M De Bellis
P Tortorella
P2860
P304
P3181
P356
10.1038/SJ.BJP.0704366
P407
P577
2001-12-01T00:00:00Z