Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.
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Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmiasThe hitchhiker's guide to the voltage-gated sodium channel galaxyResidue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels.Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivoMexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channelFolding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.Neurotoxins and their binding areas on voltage-gated sodium channels.Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsAnalysis of the action of lidocaine on insect sodium channels.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.Sodium channel inactivation: molecular determinants and modulation.Molecular action of lidocaine on the voltage sensors of sodium channelsBlock of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel functionRole of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticidesNovel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels.Animal toxins influence voltage-gated sodium channel function.Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6.Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule.Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.Suppression of insulin signalling by a synthetic peptide KIFMK suggests the cytoplasmic linker between DIII-S6 and DIV-S1 as a local anaesthetic binding site on the sodium channel.Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.Cu2+ (1,10 phenanthroline)3 is an open-channel blocker of the human skeletal muscle sodium channel.Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels.Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels.Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation.Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensitivity.Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics.Asymmetric synthesis of batrachotoxin: Enantiomeric toxins show functional divergence against NaV.
P2860
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P2860
Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Residues in Na
@nl
Residues in Na(+) channel D3-S ...... d local anesthetic affinities.
@ast
Residues in Na(+) channel D3-S ...... d local anesthetic affinities.
@en
type
label
Residues in Na
@nl
Residues in Na(+) channel D3-S ...... d local anesthetic affinities.
@ast
Residues in Na(+) channel D3-S ...... d local anesthetic affinities.
@en
prefLabel
Residues in Na
@nl
Residues in Na(+) channel D3-S ...... d local anesthetic affinities.
@ast
Residues in Na(+) channel D3-S ...... d local anesthetic affinities.
@en
P2093
P2860
P1433
P1476
Residues in Na(+) channel D3-S ...... d local anesthetic affinities.
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(00)76390-9
P407
P577
2000-09-01T00:00:00Z