Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors - Wikidata - awgldk - TriplyDB

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

http://www.wikidata.org/entity/Q28366271

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Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists Pharmacology of nociceptin and its receptor: a novel therapeutic target Highly selective agonists for substance P receptor subtypes Delta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neurones Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene Nociceptin produces antinociception after spinal administration in amphibians The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Xendorphin B1, a novel opioid-like peptide determined from a Xenopus laevis brain cDNA library, produces opioid antinociception after spinal administration in amphibians Development of neuropeptide drugs that cross the blood-brain barrier."DAKLI": a multipurpose ligand with high affinity and selectivity for dynorphin (kappa opioid) binding sites A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands.Delta-opiate DPDPE in magnetically oriented phospholipid micelles: binding and arrangement of aromatic pharmacophores.The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.Complementarity of delta opioid ligand pharmacophore and receptor models.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints.Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.N-methylated cyclic enkephalin analogues retain high opioid receptor binding affinity.Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).New reagents, reactions, and peptidomimetics for drug design.Organic chemistry and biology: chemical biology through the eyes of collaboration.Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteins Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography.Evidence for lack of modulation of mu-opioid agonist action by delta-opioid agonists in the mouse vas deferens and guinea-pig ileum.Dissociation of the opioid receptor mechanisms that control mechanical and heat pain Presynaptic opioid receptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortex New paradigms and tools in drug design for pain and addiction Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon.Delta-opioid receptors mediate inhibition of fast excitatory postsynaptic potentials in cat parasympathetic colonic ganglia.Evaluation of opioid-induced antinociceptive effects in anaesthetized and conscious animals.Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins Modulation of peristalsis in the guinea-pig isolated small intestine by exogenous and endogenous opioids.Opioid activity of dermenkephalin analogues in the guinea-pig myenteric plexus and the hamster vas deferens.

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P2860

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

http://www.wikidata.org/entity/Q28366271

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1983 nî lūn-bûn

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1983 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1983 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1983年の論文

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1983年論文

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Bis-penicillamine enkephalins ...... toward delta opioid receptors

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Bis-penicillamine enkephalins ...... toward delta opioid receptors

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Bis-penicillamine enkephalins ...... toward delta opioid receptors

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Bis-penicillamine enkephalins ...... toward delta opioid receptors

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Bis-penicillamine enkephalins ...... toward delta opioid receptors

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Bis-penicillamine enkephalins ...... toward delta opioid receptors

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Proceedings of the National Academy of Sciences of the United States of America

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Bis-penicillamine enkephalins ...... toward delta opioid receptors

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H I Mosberg

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H I Yamamura

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J J Galligan

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R Hurst

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T F Burks

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V J Hruby

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P2860

Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.

Endogenous opioid peptides: multiple agonists and receptors.

Relative conformational rigidity in oxytocin and (1-penicillamine)-oxytocin: a proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism.

Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics

The effects of adrenaline, noradrenaline and isoprenaline on inhibitory alpha- and beta-adrenoceptors in the longitudinal muscle of the guinea-pig ileum.

Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with mu- and delta-receptors.

Comparison of the binding characteristics of tritiated opiates and opioid peptides.

Spectrum of the mu, delta- and kappa-binding sites in homogenates of rat brain.

Classification of multiple morphine and enkephalin binding sites in the central nervous system

A cyclic enkephalin analog with high in vitro opiate activity.

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