Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1 - Wikidata - awgldk - TriplyDB

Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

http://www.wikidata.org/entity/Q28367561

about

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends Inhibition of Ape1 nuclease activity by lead, iron, and cadmium.The current state of eukaryotic DNA base damage and repair Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis risk Overview of base excision repair biochemistry Solution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformation Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesion 3'-phosphodiesterase and 3'-->5' exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage.Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA In situ activity gel for DNA repair 3'-phosphodiesterase.3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3'-phosphoglycolate termini.Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast.Dynamics and diversions in base excision DNA repair of oxidized abasic lesions.Removal of reactive oxygen species-induced 3'-blocked ends by XPF-ERCC1.Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.DNA damage and repair: relevance to mechanisms of neurodegeneration Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.Characterization of the promoter region of the human apurinic endonuclease gene (APE).Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry.Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines.DNA repair functions in heterologous cells.APE1 is the major 3'-phosphoglycolate activity in human cell extracts Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma Development of a high-throughput screening platform for DNA 3'-phosphatases and their inhibitors based on a universal molecular beacon and quantitative real-time PCR.CiAPEX2 and CiP0, candidates of AP endonucleases in Ciona intestinalis, have 3'-5' exonuclease activity and contribute to protection against oxidative stress.The Photorespiratory Metabolite 2-Phosphoglycolate Regulates Photosynthesis and Starch Accumulation in Arabidopsis.Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.Drosophila Rrp1 domain structure as defined by limited proteolysis and biophysical analyses.

P2860

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P2860

Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

http://www.wikidata.org/entity/Q28367561

description

1994 nî lūn-bûn

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1994 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1994 թվականի մայիսին հրատարակված գիտական հոդված

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1994年の論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年论文

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name

Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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type

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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Nucleic Acids Research

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Removal of 3'-phosphoglycolate ...... ic/apyrimidinic endonuclease 1

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P2093

A McCullough

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P S Russell

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T A Winters

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T J Jorgensen

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W D Henner

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P2860

DNA sequencing with chain-terminating inhibitors

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes

Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants

Nucleotide sequence of a cDNA for an apurinic/apyrimidinic endonuclease from HeLa cells

The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Sequencing end-labeled DNA with base-specific chemical cleavages

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Human HeLa cell enzymes that remove phosphoglycolate 3'-end groups from DNA.

Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide.

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1866-73

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scholarly article

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10.1093/NAR/22.10.1866

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10

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22

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15683171

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7516064

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308086

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