Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs - Wikidata - awgldk - TriplyDB

Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs

Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs

http://www.wikidata.org/entity/Q28373081

about

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability DNA repair and gene therapy: implications for translational uses.Overexpression of enzymes that repair endogenous damage to DNA.Base excision repair in a network of defence and tolerance.Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis.Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice.Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.Programming of Cell Resistance to Genotoxic and Oxidative Stress.

P2860

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P2860

Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs

http://www.wikidata.org/entity/Q28373081

description

1999 nî lūn-bûn

@nan

1999 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի մարտին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Overexpression of the human HA ...... l effect of bioreductive drugs

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Overexpression of the human HA ...... l effect of bioreductive drugs

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Overexpression of the human HA ...... l effect of bioreductive drugs

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type

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Overexpression of the human HA ...... l effect of bioreductive drugs

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Overexpression of the human HA ...... l effect of bioreductive drugs

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Overexpression of the human HA ...... l effect of bioreductive drugs

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prefLabel

Overexpression of the human HA ...... l effect of bioreductive drugs

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Overexpression of the human HA ...... l effect of bioreductive drugs

@en

Overexpression of the human HA ...... l effect of bioreductive drugs

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Overexpression of the human HA ...... l effect of bioreductive drugs

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F Laval

http://www.w3.org/2001/XMLSchema#string

M J Prieto-Alamo

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P2860

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes

Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1

Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants

Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase

Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast.

Role of cysteine residues in regulation of p53 function.

Repair of intrinsic DNA lesions.

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

Expression of the E. coli fpg gene in mammalian cells reduces the mutagenicity of gamma-rays.

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415-9

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scholarly article

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10.1093/CARCIN/20.3.415

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3

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10190555

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