Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds - Wikidata - awgldk - TriplyDB

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

http://www.wikidata.org/entity/Q28368059

about

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors Current Landscape of Antiviral Drug Discovery The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors 3-Hydroxyquinolin-2(1 H )-ones As Inhibitors of Influenza A Endonuclease The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design New small-molecule drug design strategies for fighting resistant influenza A Inhibition of human immunodeficiency virus integrase by bis-catechols A novel antiviral agent which inhibits the endonuclease of influenza viruses Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells Mammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus.Structures of influenza A proteins and insights into antiviral drug targets.Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.Identification of potential influenza virus endonuclease inhibitors through virtual screening based on the 3D-QSAR model.Approaches and strategies for the treatment of influenza virus infections.Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.Fragment-Based Identification of Influenza Endonuclease Inhibitors.A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase.3D Molecular Modelling Study of the H7N9 RNA-Dependent RNA Polymerase as an Emerging Pharmacological Target Structure-function studies of the influenza virus RNA polymerase PA subunit.Computation-guided discovery of influenza endonuclease inhibitors.Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions.Recent advances in pharmacophore modeling and its application to anti-influenza drug discovery.Potential therapeutic applications of RNA cap analogs.Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.Antiviral strategies against influenza virus: towards new therapeutic approaches.Cross-protection of influenza A virus infection by a DNA aptamer targeting the PA endonuclease domain.Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza.

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P2860

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

http://www.wikidata.org/entity/Q28368059

description

1994 nî lūn-bûn

@nan

1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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1994年の論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年论文

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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Antimicrobial Agents and Chemotherapy

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Inhibition of cap (m7GpppXm)-d ...... 4-dioxobutanoic acid compounds

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P2860

Amino acid sequence of the mRNA cap-binding protein from human tissues

Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription.

Molecular model of a eucaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription.

mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Purification and physical properties

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity

Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses

Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine.

Purification and molecular structure of RNA polymerase from influenza virus A/PR8.

Biochemical studies on capped RNA primers identify a class of oligonucleotide inhibitors of the influenza virus RNA polymerase.

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12

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