Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.
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Fluorescence anisotropy (polarization): from drug screening to precision medicine.Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA EndonucleaseStructural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) PolymeraseCrystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease InhibitorsThe Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug DesignMutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonucleaseCharacterisation of the Candida albicans Phosphopantetheinyl Transferase Ppt2 as a Potential Antifungal Drug TargetProgress of small molecular inhibitors in the development of anti-influenza virus agents.A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In VitroScreening methods for influenza antiviral drug discovery.Identification of two-step chemical mechanisms using small temperature oscillations and a single tagged species.Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.Fragment-Based Identification of Influenza Endonuclease Inhibitors.Kinetics of binding of fluorescent ligands to enzymes with engineered access tunnels.A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase.Computation-guided discovery of influenza endonuclease inhibitors.New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions.Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.Stacking with No Planarity?Fluorescence polarization assays in high-throughput screening and drug discovery: a reviewProtein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.
P2860
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P2860
Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Identification of influenza en ...... uorescence polarization assay.
@ast
Identification of influenza en ...... uorescence polarization assay.
@en
type
label
Identification of influenza en ...... uorescence polarization assay.
@ast
Identification of influenza en ...... uorescence polarization assay.
@en
prefLabel
Identification of influenza en ...... uorescence polarization assay.
@ast
Identification of influenza en ...... uorescence polarization assay.
@en
P2093
P2860
P356
P1433
P1476
Identification of influenza en ...... uorescence polarization assay.
@en
P2093
Brandi M Baughman
P Jake Slavish
Rebecca M DuBois
Stephen W White
Thomas R Webb
Vincent A Boyd
P2860
P304
P356
10.1021/CB200439Z
P577
2012-01-19T00:00:00Z