Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses
about
Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cellsThe integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behaviorCOX-2 inhibitors vs. NSAIDs in gastrointestinal damage and preventionAlpha4 integrins and the immune responseInhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseasesThe Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesionGalphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion.Integrins as Therapeutic Targets for Respiratory DiseasesTherapeutic strategies for allergic diseases.Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion.Novel therapy for asthma.A 3D structure model of integrin alpha 4 beta 1 complex: I. Construction of a homology model of beta 1 and ligand binding analysisFRET detection of cellular alpha4-integrin conformational activation.Drugs, inflammation and cell adhesion receptors.Antiadhesion molecule therapy in inflammatory bowel disease.T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells.Conformational mAb as a tool for integrin ligand discoveryReal-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization.Actual therapeutic management of allergic and hyperreactive nasal disorders5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists.Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis.Alpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injuryLymphocyte trafficking to inflamed skin--molecular mechanisms and implications for therapeutic target molecules.Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domainMobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4.Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma.Overview: assays for studying integrin-dependent cell adhesion.Role of integrin alpha4 in drug resistance of leukemiaQuantification of integrin receptor agonism by fluorescence lifetime imaging.Integrin Ligands with α/β-Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects.Measurement of VLA-4/CS-1 and VLA-4/VCAM adhesion inhibition.Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation.Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide.Integrins as Therapeutic Targets: Successes and Cancers.Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.Conformational regulation of the fibronectin binding and alpha 3beta 1 integrin-mediated adhesive activities of thrombospondin-1.
P2860
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P2860
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Selective, tight-binding inhib ...... ibit allergic airway responses
@ast
Selective, tight-binding inhib ...... ibit allergic airway responses
@en
Selective, tight-binding inhib ...... ibit allergic airway responses
@nl
type
label
Selective, tight-binding inhib ...... ibit allergic airway responses
@ast
Selective, tight-binding inhib ...... ibit allergic airway responses
@en
Selective, tight-binding inhib ...... ibit allergic airway responses
@nl
prefLabel
Selective, tight-binding inhib ...... ibit allergic airway responses
@ast
Selective, tight-binding inhib ...... ibit allergic airway responses
@en
Selective, tight-binding inhib ...... ibit allergic airway responses
@nl
P2093
P356
P1476
Selective, tight-binding inhib ...... ibit allergic airway responses
@en
P2093
A G Sprague
C E Hammond
C N Zimmerman
P304
P356
10.1021/JM980673G
P407
P577
1999-03-11T00:00:00Z