Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes
about
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17Role of diacylglycerol kinase alpha in the attenuation of receptor signalingForeign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022Diacylglycerol kinases in membrane traffickingDiacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytesFatty acids inhibit growth-factor-induced diacylglycerol kinase alpha activation in vascular smooth-muscle cellsDual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists.Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytesDiacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDIDiacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responsesPhosphatidic acid plays a regulatory role in clathrin-mediated endocytosis.Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.Diacylglycerol Kinase Inhibition and Vascular FunctionNuclear diacylglycerol lipase-α in rat brain cortical neurons: evidence of 2-arachidonoylglycerol production in concert with phospholipase C-β activity.Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response.Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes.Bacterial expression strategies for several Sus scrofa diacylglycerol kinase alpha constructs: solubility challenges.Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes.Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms.The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophyChemical modulation of glycerolipid signaling and metabolic pathways.Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility.A domain with homology to neuronal calcium sensors is required for calcium-dependent activation of diacylglycerol kinase alpha.The Arabidopsis DREB2 genetic pathway is constitutively repressed by basal phosphoinositide-dependent phospholipase C coupled to diacylglycerol kinase.Diacylglycerol kinases are essential for hepatocyte growth factor-dependent proliferation and motility of Kaposi's sarcoma cells.Massive Ca-induced membrane fusion and phospholipid changes triggered by reverse Na/Ca exchange in BHK fibroblasts.T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.Diacylglycerol kinase-dependent formation of phosphatidic acid molecular species during interleukin-2 activation in CTLL-2 T-lymphocytes.Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.Site-directed mutagenesis of the active site of diacylglycerol kinase alpha: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanisms.RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.R59949, a diacylglycerol kinase inhibitor, inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells.Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning.Phosphatidic acid and diacylglycerol directly activate NADPH oxidase by interacting with enzyme components.
P2860
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P2860
Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@ast
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@en
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@nl
type
label
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@ast
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@en
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@nl
prefLabel
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@ast
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@en
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@nl
P2093
P1476
Selectivity of the diacylglyce ...... diacylglycerol kinase subtypes
@en
P2093
P304
P356
10.1016/S0006-2952(99)00395-0
P407
P577
2000-04-01T00:00:00Z