Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
about
Rapamycin and mTOR kinase inhibitorsSynergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cellsRasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy.Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell deathChloroquine synergizes with FTS to enhance cell growth inhibition and cell deathHuman leukaemic stem cells: a novel target of therapy.Phase I study of S-trans, trans-farnesylthiosalicylic acid (salirasib), a novel oral RAS inhibitor in patients with refractory hematologic malignancies.Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmissionRas as a therapeutic target in hematologic malignancies.Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxideSalirasib in the treatment of pancreatic cancer.Ras and autophagy in cancer development and therapy.Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?Ras inhibition enhances autophagy, which partially protects cells from death.Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins.Ras nanoclusters: a new drug target?Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis.Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum.Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry.Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice.Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.Protein Prenylation: An (Almost) Comprehensive Overview on Discovery History, Enzymology, and Significance in Physiology and Disease
P2860
Q24644623-C36720B1-E474-4B50-932A-5A56EFFEF080Q28485464-6946DD8C-CECF-4989-95A1-167F7211B3B7Q33720198-46321A8A-D345-4ABC-91E4-697EF989850EQ34276668-07571577-B893-4623-AD9E-2450081EAD9AQ34708324-0E9F0B7E-85AD-4520-AFF3-4A710CB93352Q35005500-1B1FE5AD-19F1-4065-B541-7E0D3CF70679Q35076007-3E89716C-78EC-4BB3-9EC0-A12ACFE69605Q35854964-56B77393-0048-47BF-9FDA-C5482EC32A7BQ35872060-659232AA-26FD-4F85-8CF2-F4CA566311C3Q36559712-4913879F-4AE7-4B77-9D73-E6A3CAD8B56FQ36866611-1425DE18-0560-4BF0-B836-1631D58CDFA8Q37447885-64122204-97E6-4F6B-8957-BBF3DD8938D6Q37712302-60E297DB-8434-4DA9-96B3-FB782583AC7DQ37763095-788E45CD-12AE-40F5-A222-B694C3967806Q38192416-B2387F77-CD3C-45BB-9AA9-5B78B8B37F05Q38423044-3191CE8F-A192-4961-A3AF-C141D20DB8A6Q39201276-3A15350F-F6A9-491C-A0C6-D0C1BD166D81Q39249805-514E585E-EE03-4B2F-821C-0F443D05712CQ39465453-250ECF30-ECA0-4344-A6ED-AC1F2A4A811BQ39557202-EFB8ABDA-9206-44D3-BC7B-0616C1A57846Q40968194-A1E41702-2EDE-4E48-9684-77B191B37303Q41764136-01F87E2C-6AD4-4320-8295-624916AFBE15Q42364777-768970B2-B7A2-4CDE-9D88-CD6BED393756Q42560081-6A5AE739-46D2-4144-A472-F3534DDF7302Q51119632-4FC2E69C-911F-42E9-857C-C4C6EB392694Q53222425-ADA8B6A8-8D70-41F1-A36B-71876B5A0513Q57357264-89FF73D2-BB17-44CE-A476-3F188636BCB2
P2860
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@ast
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@en
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@nl
type
label
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@ast
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@en
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@nl
prefLabel
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@ast
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@en
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@nl
P2093
P1476
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
@en
P2093
P304
P356
10.1016/S0167-4889(99)00144-5
P407
P577
1999-12-09T00:00:00Z