Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission
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The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and ProgressionActivation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer.Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like CellsNovel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophagesSignal integration by lipid-mediated spatial cross talk between Ras nanoclustersA high-throughput assay for small molecule destabilizers of the KRAS oncoproteinTargeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.Oligomycins as inhibitors of K-Ras plasma membrane localisation.Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane.Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.KRAS - An Evolving Cancer TargetLessons from computer simulations of Ras proteins in solution and in membraneAnother surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy.AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling.Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling.Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?Computational allosteric ligand binding site identification on Ras proteins.Drugging RAS: Know the enemy.Comparative proteomic analysis of compartmentalised Ras signalling.Deciphering lipid codes: K-Ras as a paradigm.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor.Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins.Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output.Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.Positive feedback can lead to dynamic nanometer-scale clustering on cell membranes.Sphingomyelin metabolism is a regulator of KRAS function.
P2860
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P2860
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Fendiline inhibits K-Ras plasm ...... ocks K-Ras signal transmission
@ast
Fendiline inhibits K-Ras plasm ...... ocks K-Ras signal transmission
@en
type
label
Fendiline inhibits K-Ras plasm ...... ocks K-Ras signal transmission
@ast
Fendiline inhibits K-Ras plasm ...... ocks K-Ras signal transmission
@en
prefLabel
Fendiline inhibits K-Ras plasm ...... ocks K-Ras signal transmission
@ast
Fendiline inhibits K-Ras plasm ...... ocks K-Ras signal transmission
@en
P2093
P2860
P356
P1476
Fendiline inhibits K-Ras plasm ...... ocks K-Ras signal transmission
@en
P2093
Dharini van der Hoeven
John F Hancock
Kwang-jin Cho
Robert G Parton
Sravanthi Chigurupati
Xiaoping Ma
P2860
P304
P356
10.1128/MCB.00884-12
P407
P577
2012-11-05T00:00:00Z