Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
about
GSK-3β: A Bifunctional Role in Cell Death PathwaysGlycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response elementGenomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridolTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsHigh-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitorChemical modulation of memory formation in larval zebrafish.Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.Human cytomegaloviruses expressing yellow fluorescent fusion proteins--characterization and use in antiviral screening.Inhibition of human immunodeficiency virus type-1 by cdk inhibitorsEffect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids.Mechanism targeted discovery of antitumor marine natural products.Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacyEukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles.Ruthenium- and Osmium-Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity.Target identification and mechanism of action in chemical biology and drug discovery.Selectivity and potency of cyclin-dependent kinase inhibitors.Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.Protein kinase inhibitors that inhibit induction of lytic program and replication of Epstein-Barr virus.Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation.Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing EffectProliferation rate of somatic cells affects reprogramming efficiency.Dicopper(II) and dizinc(II) complexes with nonsymmetric dinucleating ligands based on indolo[3,2-c]quinolines: synthesis, structure, cytotoxicity, and intracellular distribution.Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.Genomics: applications in mechanism elucidation.Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells.Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cellsRuthenium- and osmium-arene complexes of 8-substituted indolo[3,2-c]quinolines: Synthesis, X-ray diffraction structures, spectroscopic properties, and antiproliferative activity.The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis.10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss.Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals.CDK4 inhibitors an emerging strategy for the treatment of melanoma
P2860
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P2860
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Discovery and initial characte ...... rs of cyclin-dependent kinases
@ast
Discovery and initial characte ...... rs of cyclin-dependent kinases
@en
Discovery and initial characte ...... rs of cyclin-dependent kinases
@nl
type
label
Discovery and initial characte ...... rs of cyclin-dependent kinases
@ast
Discovery and initial characte ...... rs of cyclin-dependent kinases
@en
Discovery and initial characte ...... rs of cyclin-dependent kinases
@nl
prefLabel
Discovery and initial characte ...... rs of cyclin-dependent kinases
@ast
Discovery and initial characte ...... rs of cyclin-dependent kinases
@en
Discovery and initial characte ...... rs of cyclin-dependent kinases
@nl
P2093
P1433
P1476
Discovery and initial characte ...... rs of cyclin-dependent kinases
@en
P2093
A M Senderowicz
D W Zaharevitz
E A Sausville
P304
P407
P577
1999-06-01T00:00:00Z