Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells
about
High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitorGlucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cellsIdentification of clinically used drugs that activate pregnane X receptorsProtein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.Pregnane X receptor and drug-induced liver injury.Overcoming drug resistance by regulating nuclear receptors.Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cellsThiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discoveryFunctional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.Intrinsic sexually dimorphic expression of the principal human CYP3A4 correlated with suboptimal activation of GH/glucocorticoid-dependent transcriptional pathways in men.Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoSmall-molecule modulators of PXR and CAR.Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Role of CAR and PXR in xenobiotic sensing and metabolism.Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression.A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay.PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis.A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cellsLong-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.Identification and characterization of phosphorylation sites within the pregnane X receptor protein.Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.PXR cross-talks with internal and external signals in physiological and pathophysiological responses.Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.SPA70 is a potent antagonist of human pregnane X receptor.The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor.Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner.
P2860
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P2860
Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cyclin-dependent kinase 2 nega ...... in HepG2 liver carcinoma cells
@en
Cyclin-dependent kinase 2 nega ...... n HepG2 liver carcinoma cells.
@nl
type
label
Cyclin-dependent kinase 2 nega ...... in HepG2 liver carcinoma cells
@en
Cyclin-dependent kinase 2 nega ...... n HepG2 liver carcinoma cells.
@nl
prefLabel
Cyclin-dependent kinase 2 nega ...... in HepG2 liver carcinoma cells
@en
Cyclin-dependent kinase 2 nega ...... n HepG2 liver carcinoma cells.
@nl
P2093
P2860
P356
P1476
Cyclin-dependent kinase 2 nega ...... in HepG2 liver carcinoma cells
@en
P2093
Fu-Yue Zeng
Hanqing Dong
Taosheng Chen
Wenwei Lin
P2860
P304
30650-30657
P356
10.1074/JBC.M806132200
P407
P577
2008-09-09T00:00:00Z