Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase
about
The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intakeEfficacies of lipophilic inhibitors of dihydrofolate reductase against parasitic protozoaIsolation of rat dihydrofolate reductase gene and characterization of recombinant enzymeDicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlationsStructure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase6,7-disubstituted 2,4-diaminopteridines: novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductaseIdentification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium aviumLigand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.Towards in silico lead optimization: scores from ensembles of protein/ligand conformations reliably correlate with biological activity.Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application.Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors.Use of Toxoplasma gondii expressing beta-galactosidase for colorimetric assessment of drug activity in vitroMetabolic pathway analysis and molecular docking analysis for identification of putative drug targets in Toxoplasma gondii: novel approachSynthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Simple and efficient model systems of screening anti-Toxoplasma drugs in vitro.Pyrimethamine-loaded lipid-core nanocapsules to improve drug efficacy for the treatment of toxoplasmosis.Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design.Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes.Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro
P2860
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P2860
Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase
description
1993 nî lūn-bûn
@nan
1993 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Identification of highly poten ...... gondii dihydrofolate reductase
@ast
Identification of highly poten ...... gondii dihydrofolate reductase
@en
Identification of highly poten ...... gondii dihydrofolate reductase
@nl
type
label
Identification of highly poten ...... gondii dihydrofolate reductase
@ast
Identification of highly poten ...... gondii dihydrofolate reductase
@en
Identification of highly poten ...... gondii dihydrofolate reductase
@nl
prefLabel
Identification of highly poten ...... gondii dihydrofolate reductase
@ast
Identification of highly poten ...... gondii dihydrofolate reductase
@en
Identification of highly poten ...... gondii dihydrofolate reductase
@nl
P2860
P356
P1476
Identification of highly poten ...... gondii dihydrofolate reductase
@en
P2093
P2860
P304
P356
10.1128/AAC.37.9.1914
P407
P577
1993-09-01T00:00:00Z