Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors.
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PoLi: A Virtual Screening Pipeline Based on Template Pocket and Ligand Similarity.Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.On the importance of composite protein multiple ligand interactions in protein pockets.Catalytic and substrate promiscuity: distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase.Novel small molecule binders of human N-glycanase 1, a key player in the endoplasmic reticulum associated degradation pathway.Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFRRational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.
P2860
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P2860
Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors.
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2015 nî lūn-bûn
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2015 թուականի Մարտին հրատարակուած գիտական յօդուած
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2015 թվականի մարտին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
@zh-hk
2015年論文
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2015年論文
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2015年论文
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name
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@ast
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@en
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@nl
type
label
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@ast
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@en
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@nl
prefLabel
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@ast
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@en
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@nl
P2860
P356
P1433
P1476
Insights into the slow-onset t ...... ovel tight-binding inhibitors.
@en
P2093
Bharath Srinivasan
P2860
P304
P356
10.1111/FEBS.13244
P407
P577
2015-03-06T00:00:00Z