Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil
about
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinaseIn vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracilThe polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistanceInhibition of replication of hepatitis B virus by cytallene in vitroInhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication.Unique metabolism of a novel antiviral L-nucleoside analog, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil: a substrate for both thymidine kinase and deoxycytidine kinaseClonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection.A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseaseBehavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.Treatment outcomes of clevudine versus lamivudine at week 48 in naïve patients with HBeAg positive chronic hepatitis B.Identification and characterization of clevudine-resistant mutants of hepatitis B virus isolated from chronic hepatitis B patients.Characterization of novel human hepatoma cell lines with stable hepatitis B virus secretion for evaluating new compounds against lamivudine- and penciclovir-resistant virus.High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells.Comparison of anti-hepatitis B virus activities of lamivudine and clevudine by a quantitative assay.A comparison of 48-week treatment efficacy between clevudine and entecavir in treatment-naïve patients with chronic hepatitis B.Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development.Long-term treatment efficacy and safety of clevudine therapy in naïve patients with chronic hepatitis B.Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B.Fluorinated Nucleosides: Synthesis and Biological ImplicationNoncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine.A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.Current Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B.Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication.Understanding the molecular basis of HBV drug resistance by molecular modeling.Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy- and 5-methyl-beta-L-deoxycytidine analogues.Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.Utility of 2-thioxo-pyrido[2,3-d]pyrimidinone in synthesis of pyridopyrimido[2,1-b][1,3,5]-thiadiazinones and pyridopyrimido[2,1-b][1,3]thiazinones as antimicrobial agents.
P2860
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P2860
Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil
description
1996 nî lūn-bûn
@nan
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@ast
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@en
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@nl
type
label
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@ast
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@en
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@nl
prefLabel
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@ast
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@en
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@nl
P2093
P2860
P1476
Inhibition of hepatitis B viru ...... beta-L-arabinofuranosyl uracil
@en
P2093
P2860
P407
P577
1996-02-01T00:00:00Z