Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
about
A Recombinant Human Pluripotent Stem Cell Line Stably Expressing Halide-Sensitive YFP-I152L for GABAAR and GlyR-Targeted High-Throughput Drug Screening and Toxicity Testing.A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitorsReference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data GenerationInternational STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposesCombination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library.Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assayIn vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening.A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity.Impairment of human neural crest cell migration by prolonged exposure to interferon-beta.Current State of Developmental Neurotoxicology Research.From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data.Whole genome microarray analysis of neural progenitor C17.2 cells during differentiation and validation of 30 neural mRNA biomarkers for estimation of developmental neurotoxicity.Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.Rotenone exerts developmental neurotoxicity in a human brain spheroid model.Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N-methyl-d-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children.Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods.
P2860
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P2860
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@ast
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@en
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@nl
type
label
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@ast
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@en
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@nl
prefLabel
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@ast
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@en
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@nl
P2093
P2860
P3181
P356
P1476
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities
@en
P2093
Helena T Hogberg
Lena Smirnova
Thomas Hartung
P2860
P304
P3181
P356
10.14573/ALTEX.1403271
P407
P50
P577
2014-01-01T00:00:00Z