Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor
about
Carboxy-terminus of CXCR7 regulates receptor localization and functionAllosteric Modulation of Chemoattractant ReceptorsHeparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesisIdentification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cellsSite-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites.CXCL12 and [N33A]CXCL12 in 5637 and HeLa cells: regulating HER1 phosphorylation via calmodulin/calcineurin.An essential role of the cytoplasmic tail of CXCR4 in G-protein signaling and organogenesis.Oligoclonality, impaired class switch and B-cell memory responses in WHIM syndromeThe CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome.The chemokine CXCL12 is essential for the clearance of the filaria Litomosoides sigmodontis in resistant miceA phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixaforHierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion.G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.Genetics on a WHIM.Regulation of neutrophil trafficking from the bone marrow.β-Arrestins in the immune systemTargeted strategies directed at the molecular defect: Toward precision medicine for select primary immunodeficiency disorders.Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.MIM regulates the trafficking of bone marrow cells via modulating surface expression of CXCR4.Prognostic value of decreased GRK6 expression in lung adenocarcinoma.Functional consequences of perturbed CXCL12 signal processing: analyses of immature hematopoiesis in GRK6-deficient mice.Stage-specific roles for CXCR4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation.G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling.Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases.Pathogenesis, diagnosis and therapeutic strategies in WHIM syndrome immunodeficiency.G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin.Flow cytometry analysis of receptor internalization/shedding.
P2860
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P2860
Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@ast
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@en
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@nl
type
label
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@ast
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@en
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@nl
prefLabel
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@ast
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@en
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@nl
P2093
P2860
P3181
P1433
P1476
Impaired recruitment of Grk6 a ...... sociated CXCR4 mutant receptor
@en
P2093
A Virginia Gulino
Giovanna Tosato
Marta Segarra
Paola Gasperini
P2860
P3181
P356
10.1371/JOURNAL.PONE.0008102
P407
P577
2009-12-01T00:00:00Z