Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth - Wikidata - awgldk - TriplyDB

Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth

Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth

http://www.wikidata.org/entity/Q28473419

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Targeting TGF-β signaling in cancer Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy Complexities of TGF-β targeted cancer therapy.Treatment of multiple myeloma bone disease: experimental and clinical data.Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics Bone disease in multiple myeloma: pathophysiology and management.Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model.Bone anabolic agents for the treatment of multiple myeloma.Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation.Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma Dissecting the multiple myeloma-bone microenvironment reveals new therapeutic opportunities Targeting the TGFβ signalling pathway in disease.Novel Bruton's tyrosine kinase inhibitors currently in development.Small Molecule Inhibition of Transforming Growth Factor Beta Signaling Enables the Endogenous Regenerative Potential of the Mammalian Calvarium.Mechanisms of multiple myeloma bone disease.Kinase inhibitors as potential agents in the treatment of multiple myeloma.Tumor-host cell interactions in the bone disease of myeloma.Adipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone.Molecular mechanisms, current management and next generation therapy in myeloma bone disease.Adipose, Bone, and Myeloma: Contributions from the Microenvironment.Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.Targeting TGF-β Signaling for Therapeutic Gain.Transforming growth factor-β: A therapeutic target for cancer.Up-regulation of hexokinaseII in myeloma cells: targeting myeloma cells with 3-bromopyruvate.KRN5500, a spicamycin derivative, exerts anti-myeloma effects through impairing both myeloma cells and osteoclasts.Co-culture of human bone marrow stromal cells with endothelial cells alters gene expression profiles.Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma.The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells.A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration Bone-Conditioned Medium Inhibits Osteogenic and Adipogenic Differentiation of Mesenchymal Cells In Vitro.Activating transcription factor 4, an ER stress mediator, is required for, but excessive ER stress suppresses osteoblastogenesis by bortezomib.Upregulation of long non-coding RNA HIF 1α-anti-sense 1 induced by transforming growth factor-β-mediated targeting of sirtuin 1 promotes osteoblastic differentiation of human bone marrow stromal cells.Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma.Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.Pathogenesis of bone disease in multiple myeloma: from bench to bedside.Mechanisms of bone destruction in multiple myeloma.Direct phenotypic conversion of human fibroblasts into functional osteoblasts triggered by a blockade of the transforming growth factor-β signal.Myeloma bone disease: Pathophysiology and management.

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Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth

http://www.wikidata.org/entity/Q28473419

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Tgf-Beta inhibition restores t ...... ion to suppress myeloma growth

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Asuka Oda

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Ayako Nakano

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Hiroe Amou

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P2860

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

High bone density due to a mutation in LDL-receptor-related protein 5

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

Bone morphogenetic proteins

Transforming growth factor-beta in osteolytic breast cancer bone metastases.

Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.

Therapy with bortezomib plus dexamethasone induces osteoblast activation in responsive patients with multiple myeloma.

TGF-beta1 regulation of dendritic cells.

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