S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton
about
Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cellsSmall molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathwaysSustained proliferation in cancer: Mechanisms and novel therapeutic targetsImage-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerizationA novel sulfonamide agent, MPSP-001, exhibits potent activity against human cancer cells in vitro through disruption of microtubule.Synthesis of phenstatin/isocombretastatin-chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers.Synthesis of 2-anilinopyridyl-triazole conjugates as antimitotic agents.Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway.Potential impact of mTOR inhibitors on cervical squamous cell carcinoma: A systematic review.An overview of tubulin inhibitors that interact with the colchicine binding siteUltrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapySynergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma.Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding SiteNew microtubule-inhibiting anticancer agents.Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function.EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells.Discovery of novel 2-N-aryl-substituted benzenesulfonamidoacetamides: orally bioavailable tubulin polymerization inhibitors with marked antitumor activities.Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity.Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors.Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction.Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors.HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.
P2860
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P2860
S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@ast
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@en
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@nl
type
label
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@ast
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@en
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@nl
prefLabel
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@ast
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@en
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@nl
P2093
P2860
P3181
P1433
P1476
S9, a novel anticancer agent, ...... g and microtubule cytoskeleton
@en
P2093
Chao Zhang
Chun-Hao Yang
Hua-Liang Jiang
Hua-Sheng Ding
Ling-Hua Meng
Mao-Jiang Wu
Xiong-Wen Zhang
P2860
P3181
P356
10.1371/JOURNAL.PONE.0004881
P407
P50
P577
2009-01-01T00:00:00Z