Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase
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Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.Variations of Subunit of the Mycobacterium tuberculosis F1Fo ATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207Multitarget drug discovery for tuberculosis and other infectious diseases.A Review of the Evidence for Using Bedaquiline (TMC207) to Treat Multi-Drug Resistant TuberculosisEnergetics of Respiration and Oxidative Phosphorylation in Mycobacteria.Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophagesMycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery.The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress.Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors.In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatmentBedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase.Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds.New treatment options for multidrug-resistant tuberculosis.Bedaquiline - The first ATP synthase inhibitor against multi drug resistant tuberculosis.Bedaquiline: a novel antitubercular agent for the treatment of multidrug-resistant tuberculosis.The anti-tuberculosis agents under development and the challenges ahead.Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery.Novel antibiotics targeting respiratory ATP synthesis in Gram-positive pathogenic bacteria.A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure.Bedaquiline.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.Asymmetric Synthesis and Absolute Configuration Assignment of a New Type of Bedaquiline Analogue.Pharmacokinetics of Bedaquiline in Cerebrospinal Fluid and Serum in Multidrug-Resistant Tuberculous Meningitis.Determination of MIC Distribution and Mechanisms of Decreased Susceptibility to Bedaquiline among Clinical Isolates of Mycobacterium abscessus.
P2860
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P2860
Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase
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2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
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2011 թվականին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
@zh-tw
2011年论文
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name
Probing the interaction of the ...... get mycobacterial ATP synthase
@ast
Probing the interaction of the ...... get mycobacterial ATP synthase
@en
Probing the interaction of the ...... get mycobacterial ATP synthase
@nl
type
label
Probing the interaction of the ...... get mycobacterial ATP synthase
@ast
Probing the interaction of the ...... get mycobacterial ATP synthase
@en
Probing the interaction of the ...... get mycobacterial ATP synthase
@nl
prefLabel
Probing the interaction of the ...... get mycobacterial ATP synthase
@ast
Probing the interaction of the ...... get mycobacterial ATP synthase
@en
Probing the interaction of the ...... get mycobacterial ATP synthase
@nl
P2093
P2860
P3181
P1433
P1476
Probing the interaction of the ...... get mycobacterial ATP synthase
@en
P2093
Anna C Haagsma
Holger Lill
Ioana Podasca
Jerome Guillemont
Koen Andries
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0023575
P407
P577
2011-01-01T00:00:00Z