Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery.
about
A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis
P2860
Q40063754-208EE1DE-AEFD-4644-98F6-7A343A9482F9Q40093529-033A3ACF-CE04-4171-8B60-44202589E71AQ40112549-FBFA0B00-6078-4E26-A912-2D042E83A091Q42242216-DEED2BCA-18C5-4E5E-917C-6E5EF65FB43CQ47133089-2559971C-9CD0-401F-864F-2908612E4F78Q47446710-ED3968E3-1324-4B71-8B13-DD371CEF523BQ48505400-96B11388-0C1A-48FE-8C3F-52E20BF4258EQ49571536-0EC8BE09-2905-4E6B-897E-F035DC62B66AQ57656314-BF9D510A-E11E-4733-AAFF-631E3A713049
P2860
Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
Targeting Energy Metabolism in ...... imycobacterial Drug Discovery.
@en
Targeting Energy Metabolism in ...... imycobacterial Drug Discovery.
@nl
type
label
Targeting Energy Metabolism in ...... imycobacterial Drug Discovery.
@en
Targeting Energy Metabolism in ...... imycobacterial Drug Discovery.
@nl
prefLabel
Targeting Energy Metabolism in ...... imycobacterial Drug Discovery.
@en
Targeting Energy Metabolism in ...... imycobacterial Drug Discovery.
@nl
P2093
P2860
P921
P356
P1433
P1476
Targeting Energy Metabolism in ...... imycobacterial Drug Discovery.
@en
P2093
Cristina Villellas
P2860
P356
10.1128/MBIO.00272-17
P577
2017-04-11T00:00:00Z