High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase
about
Kinases as druggable targets in trypanosomatid protozoan parasitesRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisUsing a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotesAn inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.Mapping the effects of drugs on the immune system.Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani.Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation.Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major.Activity of anti-cancer protein kinase inhibitors against Leishmania spp.Genetically Validated Drug Targets in Leishmania; Current Knowledge and Future Prospects.Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
P2860
Q26786761-6D314A8B-74A9-48CF-8909-BA7F31E8BB22Q27011766-FE3E5FB9-846C-47EE-B1F7-933F66F6DFFAQ28542767-C8E58828-2753-4760-B53A-FF83586F191DQ33688195-C9761262-7319-4F1D-859F-C4AEA9451261Q35213483-BF15419A-0231-4E4B-93F8-37CB9A0BD214Q36446799-D1108BAE-59B2-4AED-B4B4-19B2FD13440BQ36753140-BB09C6FD-38C2-4C8B-8499-3403DBFF1AD5Q36951476-6117F778-FD37-4EDE-B032-0D55DCA7F16DQ37020701-402B3B6F-023B-45B8-8F35-767F4C15B951Q38188571-21DF66BD-3A9E-467E-846D-0EB747425F4AQ38697065-4CAC57E5-6B76-44C5-A053-C0A67820B617Q38948559-64A515B5-2682-45B8-B443-BCBF777A327EQ39348237-85A1FCB4-3E10-4BFF-B66A-F417644E5A31Q39428089-3CF1F3C1-83FF-4538-BBB2-EC091A8E8A22Q47702679-AE13FD32-4977-4AE5-98D8-49B42C317364Q57190987-842BB185-DE4E-4444-8372-49FD1E9F3FAE
P2860
High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@ast
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@en
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@nl
type
label
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@ast
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@en
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@nl
prefLabel
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@ast
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@en
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@nl
P2093
P2860
P50
P3181
P1476
High throughput screens yield ...... 3:CYC6 cyclin-dependent kinase
@en
P2093
David G Blake
Elaine Brown
Graeme Thomson
Kirk Malone
Matthew W Nowicki
Roderick G Walker
P2860
P3181
P356
10.1371/JOURNAL.PNTD.0001033
P407
P577
2011-04-05T00:00:00Z