about
Comparative genomic analysis of three Leishmania species that cause diverse human diseaseGuidelines for the use and interpretation of assays for monitoring autophagyThe genome of the kinetoplastid parasite, Leishmania majorThe Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseDraft genome sequence of the sexually transmitted pathogen Trichomonas vaginalisCrystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factorWhole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistanceComparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomesIn vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasisThe crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active siteStructures of Leishmania major orthologues of macrophage migration inhibitory factorBiochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory FactorCrystal structure of a Trypanosoma brucei metacaspaseHigh throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinaseIdentification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma bruceiIdentification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPBHighly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferaseRegulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screenAn essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma bruceiProteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sicknessSpecific negative charges in cysteine protease isoforms of Leishmaniamexicana are highly influential on the substrate binding and hydrolysis.Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210.Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B.Protein kinases as drug targets in parasitic protozoa.Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease.The SNARE protein family of Leishmania majorStudies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis.Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen.Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.Inhibition of Eimeria tenella CDK-related kinase 2: From target identification to lead compounds.Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenellaCytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin.ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania majorMechanism of Trypanosoma brucei gambiense resistance to human serum.Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFα and IFNβ.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jeremy C. Mottram
@ast
Jeremy C. Mottram
@en
Jeremy C. Mottram
@es
Jeremy C. Mottram
@sl
type
label
Jeremy C. Mottram
@ast
Jeremy C. Mottram
@en
Jeremy C. Mottram
@es
Jeremy C. Mottram
@sl
prefLabel
Jeremy C. Mottram
@ast
Jeremy C. Mottram
@en
Jeremy C. Mottram
@es
Jeremy C. Mottram
@sl
P106
P1153
7005613209
P2031
1985-01-01T00:00:00Z
P21
P31
P496
0000-0001-5574-3766