Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis - Wikidata - awgldk - TriplyDB

Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis

Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis

http://www.wikidata.org/entity/Q28482111

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Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock.Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.Seeking homeostasis: temporal trends in respiration, oxidation, and calcium in SOD1 G93A Amyotrophic Lateral Sclerosis mice.A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis Type I Vs. Type II Cytokine Levels as a Function of SOD1 G93A Mouse Amyotrophic Lateral Sclerosis Disease Progression.Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.Electrophilic nitro-fatty acids prevent astrocyte-mediated toxicity to motor neurons in a cell model of familial amyotrophic lateral sclerosis via nuclear factor erythroid 2-related factor activation Astrocyte-like cells derived from human oral mucosa stem cells provide neuroprotection in vitro and in vivo.The multifaceted role of glial cells in amyotrophic lateral sclerosis.Advances in cellular models to explore the pathophysiology of amyotrophic lateral sclerosis.A mitochondrial basis for Huntington's disease: therapeutic prospects.Transcriptional analysis reveals distinct subtypes in amyotrophic lateral sclerosis: implications for personalized therapy.Management and therapeutic perspectives in amyotrophic lateral sclerosis.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis.Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments Morphological changes and altered expression of antioxidant proteins in a heterozygous dynein mutant; a mouse model of spinal muscular atrophy.Implications of white matter damage in amyotrophic lateral sclerosis (Review).Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model.Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis.Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease.Energy metabolism in ALS: an underappreciated opportunity?Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis.

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Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis

http://www.wikidata.org/entity/Q28482111

description

2012 nî lūn-bûn

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2012 թուականին հրատարակուած գիտական յօդուած

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Modulation of astrocytic mitoc ...... amyotrophic lateral sclerosis

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Modulation of astrocytic mitoc ...... amyotrophic lateral sclerosis

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Modulation of astrocytic mitoc ...... amyotrophic lateral sclerosis

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Adriana Cassina

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Carmen Bolatto

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Emiliano Trías

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Laura Martínez-Palma

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Luis Barbeito

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Mandi Gandelman

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Patricia Cassina

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Rafael Radi

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P2860

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS

1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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10.1371/JOURNAL.PONE.0034776

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224053256

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22509356

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amyotrophic lateral sclerosis

dichloroacetate

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