Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay - Wikidata - awgldk - TriplyDB

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay

http://www.wikidata.org/entity/Q28482292

about

Gametocyte clearance dynamics following oral artesunate treatment of uncomplicated falciparum malaria in Malian children Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1)Recent advances in malaria drug discovery Using genetic methods to define the targets of compounds with antimalarial activity Antimalarial drug discovery - approaches and progress towards new medicines.Transmission-blocking strategies: the roadmap from laboratory bench to the community A flow cytometry-based quantitative drug sensitivity assay for all Plasmodium falciparum gametocyte stages Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase.Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen Whole-cell in vitro screening for gametocytocidal compounds.Antimalarial activity of the myxobacterial macrolide chlorotonil a.A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs Effect of fluorescent dyes on in vitro-differentiated, late-stage Plasmodium falciparum gametocytes.A quantitative high throughput assay for identifying gametocytocidal compounds Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay.Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation.Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes.Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development In Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparum High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model.Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and Mefloquine Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs.Efficacy of proveblue (methylene blue) in an experimental cerebral malaria murine model A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents.CRIMALDDI: platform technologies and novel anti-malarial drug targets.Identification of inhibitors of Plasmodium falciparum gametocyte development Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.Chemical signatures and new drug targets for gametocytocidal drug development.The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes.Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs.Novel approaches in antimalarial drug discovery.

P2860

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P2860

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay

http://www.wikidata.org/entity/Q28482292

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2012 nî lūn-bûn

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Didier Leroy

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Esperanza Herreros

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Joël Lelièvre

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Maria Jesus Almela

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Virginia Franco

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P2860

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial

Transmission-blocking activities of quinine, primaquine, and artesunate

A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle

Human malaria parasites in continuous culture

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

Flow cytometry for the evaluation of anti-plasmodial activity of drugs on Plasmodium falciparum gametocytes.

Suppressive effect of azithromycin on Plasmodium berghei mosquito stage development and apicoplast replication

A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue

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