Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC - Wikidata - awgldk - TriplyDB

Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC

Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC

http://www.wikidata.org/entity/Q28484853

about

Exploring physical and chemical factors influencing the properties of recombinant prion protein and the real-time quaking-induced conversion (RT-QuIC) assay Charge neutralization of the central lysine cluster in prion protein (PrP) promotes PrP(Sc)-like folding of recombinant PrP amyloids.Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains Heparin binding confers prion stability and impairs its aggregation.Fit-for-purpose curated database application in mass spectrometry-based targeted protein identification and validation.First demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in vitro amplification.Proteopathic tau seeding predicts tauopathy in vivo.Seeded fibrillation as molecular basis of the species barrier in human prion diseases.Detection and discrimination of classical and atypical L-type bovine spongiform encephalopathy by real-time quaking-induced conversion Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid.Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion.Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration.Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time-Quaking Induced Conversion: A Comparison with PrPSc-Infected Cell Screening Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.Factors That Improve RT-QuIC Detection of Prion Seeding Activity.Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues.PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases.Amyloid-β Activates Microglia and Regulates Protein Expression in a Manner Similar to Prions.RT-QuIC Assays for Prion Disease Detection and Diagnostics.PrP P102L and nearby lysine mutations promote spontaneous in vitro formation of transmissible prions.Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation.Clinical and laboratory features of 14 young Chinese probable sCJD patients.Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion.Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice.Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion.Structural conservation of prion strain specificities in recombinant prion protein fibrils in real-time quaking-induced conversion.Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease.Differential effects of divalent cations on elk prion protein fibril formation and stability.Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.

P2860

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P2860

Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC

http://www.wikidata.org/entity/Q28484853

description

2012 nî lūn-bûn

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2012 թուականին հրատարակուած գիտական յօդուած

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2012 թվականին հրատարակված գիտական հոդված

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2012年の論文

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Prion seeding activities of mo ...... ontent using RT-QuIC and eQuIC

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Prion seeding activities of mo ...... ontent using RT-QuIC and eQuIC

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Prion seeding activities of mo ...... ontent using RT-QuIC and eQuIC

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Prion seeding activities of mo ...... ontent using RT-QuIC and eQuIC

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JOURNAL.PONE.0048969

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Prion seeding activities of mo ...... ontent using RT-QuIC and eQuIC

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Andrew G Hughson

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Brent Race

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Christina D Orrù

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Declan King

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Gerald S Baron

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Jason M Wilham

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Sarah Vascellari

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P2860

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

Generating a prion with bacterially expressed recombinant prion protein.

Recombinant prion protein induces a new transmissible prion disease in wild-type animals.

The physical relationship between infectivity and prion protein aggregates is strain-dependent

Prion shedding from olfactory neurons into nasal secretions

PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

Eight prion strains have PrP(Sc) molecules with different conformations

Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.

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e48969

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scholarly article

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1422089

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10.1371/JOURNAL.PONE.0048969

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11

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7

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Alessandra Pani

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2012-01-01T00:00:00Z

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233385636

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23139828

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Prion protein family

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3489776

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