Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities
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Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two stepsPertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology toolsRTX proteins: a highly diverse family secreted by a common mechanismBacterial Toxins as Pathogen Weapons Against PhagocytesCalcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretionAdenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacityCyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin.Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection.Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen-presenting cells by the Bordetella RTX hemolysin moiety lacking the adenylyl cyclase domain.Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussisSelective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cellsCalpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain.Ca2+ influx and tyrosine kinases trigger Bordetella adenylate cyclase toxin (ACT) endocytosis. Cell physiology and expression of the CD11b/CD18 integrin major determinants of the entry route.The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapseBordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic formVirulence factor secretion and translocation by Bordetella species.Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines.Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin.Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis.Bordetella adenylate cyclase toxin promotes calcium entry into both CD11b+ and CD11b- cells through cAMP-dependent L-type-like calcium channels.Bordetella Adenylate Cyclase-Hemolysin Toxins.Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin.The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin.Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin.Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes.cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes.Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells.Bordetella pertussis adenylate cyclase toxin disrupts functional integrity of bronchial epithelial layers.Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8+ and CD4+ T cells.cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain.Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins
P2860
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P2860
Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities
description
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2007
@ast
im Februar 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/02/02)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/02/02)
@nl
наукова стаття, опублікована в лютому 2007
@uk
name
Third activity of Bordetella a ...... lytic and hemolytic activities
@ast
Third activity of Bordetella a ...... lytic and hemolytic activities
@en
Third activity of Bordetella a ...... lytic and hemolytic activities
@nl
type
label
Third activity of Bordetella a ...... lytic and hemolytic activities
@ast
Third activity of Bordetella a ...... lytic and hemolytic activities
@en
Third activity of Bordetella a ...... lytic and hemolytic activities
@nl
prefLabel
Third activity of Bordetella a ...... lytic and hemolytic activities
@ast
Third activity of Bordetella a ...... lytic and hemolytic activities
@en
Third activity of Bordetella a ...... lytic and hemolytic activities
@nl
P2093
P50
P3181
P356
P1476
Third activity of Bordetella a ...... lytic and hemolytic activities
@en
P2093
Ivo Konopásek
Jan Krusek
Jirí Masín
Veronika Spuláková
P304
P3181
P356
10.1074/JBC.M609979200
P407
P577
2007-02-02T00:00:00Z