A sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1
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Clinical findings in patients with GLI2 mutations--phenotypic variability.On the role of electrostatics in protein-protein interactions.Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH.Growth arrest specific 1 (GAS1) is abundantly expressed in the adult mouse central nervous systemHedgehog signaling and gastrointestinal cancerThe Hedgehog signal transduction network.GAS1 is present in the cerebrospinal fluid and is expressed in the choroid plexus of the adult rat.GAS1 induces cell death through an intrinsic apoptotic pathway.Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.Annexin A1, Annexin A2, and Dyrk 1B are upregulated during GAS1-induced cell cycle arrest.
P2860
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P2860
A sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1
description
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2009
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im Juli 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2009/07/17)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/07/17)
@nl
наукова стаття, опублікована в липні 2009
@uk
name
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@ast
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@en
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@nl
type
label
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@ast
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@en
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@nl
prefLabel
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@ast
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@en
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@nl
P2860
P921
P356
P1476
A sonic hedgehog missense muta ...... uses defective binding to GAS1
@en
P2093
Chen-Ming Fan
David C. Martinelli
P2860
P304
19169–19172
P356
10.1074/JBC.C109.011957
P407
P577
2009-07-17T00:00:00Z