Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched
about
The Hedgehog protein familyIndian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levelsMediator modulates Gli3-dependent Sonic hedgehog signalingThe structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingStructural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIPThe hedgehog receptor patched is involved in cholesterol transportHomozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips.Small molecule modulation of Smoothened activityOxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cellsInhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedMapping sonic hedgehog-receptor interactions by steric interferenceHedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteAll Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerStructural insights into proteoglycan-shaped Hedgehog signalingCentrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesisPatched acts catalytically to suppress the activity of SmoothenedA sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehogExtensive phosphorylation of Smoothened in Hedgehog pathway activationReceptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1Model of the reception of hedgehog morphogen concentration gradient: comparison with an extended range of experimental data.Smoothened goes molecular: new pieces in the hedgehog signaling puzzleGenetic and biochemical definition of the Hedgehog receptor.Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterningVisualization of Gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish.Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.Small-molecule modulators of the Sonic Hedgehog signaling pathway.Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification.Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.The sonic hedgehog signaling system as a bistable genetic switch.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligandHedgehog in the human: a possible explanation for the VATER association.New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish.Molecular dynamics simulations of sonic hedgehog-receptor and inhibitor complexes and their applications for potential anticancer agent discoveryThe C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover.Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidaseHedgehog signaling promotes medulloblastoma survival via Bc/II
P2860
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P2860
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched
description
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1999
@ast
im September 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/09/28)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/09/28)
@nl
наукова стаття, опублікована у вересні 1999
@uk
name
Sonic hedgehog protein signals ...... an apparent ligand for patched
@ast
Sonic hedgehog protein signals ...... an apparent ligand for patched
@en
Sonic hedgehog protein signals ...... an apparent ligand for patched
@nl
type
label
Sonic hedgehog protein signals ...... an apparent ligand for patched
@ast
Sonic hedgehog protein signals ...... an apparent ligand for patched
@en
Sonic hedgehog protein signals ...... an apparent ligand for patched
@nl
prefLabel
Sonic hedgehog protein signals ...... an apparent ligand for patched
@ast
Sonic hedgehog protein signals ...... an apparent ligand for patched
@en
Sonic hedgehog protein signals ...... an apparent ligand for patched
@nl
P2093
P2860
P3181
P356
P1476
Sonic hedgehog protein signals ...... an apparent ligand for patched
@en
P2093
D. J. Leahy
J. A. Porter
P. A. Beachy
T. M. Hall
P2860
P304
10992–10999
P3181
P356
10.1073/PNAS.96.20.10992
P407
P577
1999-09-28T00:00:00Z