Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice
about
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1RB regulates pancreas development by stabilizing Pdx1PRINCIPLE: a tool for associating genes with diseases via network propagation.Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells.Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cellsThe emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.Spop promotes skeletal development and homeostasis by positively regulating Ihh signalingMST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability.Effective endothelial cell and human pluripotent stem cell interactions generate functional insulin-producing beta cellsMST1: a promising therapeutic target to restore functional beta cell mass in diabetes.SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.Impact of Pdx1-associated chromatin modifiers on islet β-cells.Differential expression of speckled POZ protein, SPOP: putative regulation by miR-145.Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells.A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.β-cell preservation and regeneration for diabetes treatment: where are we now?Plasma stem cell factor levels are associated with risk of cardiovascular disease and death.Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.Uterine function in the mouse requires speckle-type poz protein.
P2860
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P2860
Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice
description
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im Oktober 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/10/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/10/01)
@nl
наукова стаття, опублікована в жовтні 2010
@uk
مقالة علمية (نشرت في أكتوبر 2010)
@ar
name
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@ast
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@en
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@nl
type
label
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@ast
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@en
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@nl
prefLabel
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@ast
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@en
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@nl
P2093
P2860
P921
P356
P1476
Pcif1 modulates Pdx1 protein s ...... function and survival in mice
@en
P2093
Corey E. Cannon
David N. Groff
Doris A. Stoffers
Jeffrey D. Singer
Kathryn C. Claiborn
Mira M. Sachdeva
P2860
P304
P356
10.1172/JCI40440
P407
P577
2010-10-01T00:00:00Z