Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus - Wikidata - awgldk - TriplyDB

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

http://www.wikidata.org/entity/Q24562726

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Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction?Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development Increased islet apoptosis in Pdx1+/- mice Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans.Fishing for Nature's Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products Mitochondrial regulation of β-cell function: maintaining the momentum for insulin release Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1 Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice Nkx2.2 regulates beta-cell function in the mature islet Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1 RB regulates pancreas development by stabilizing Pdx1 Genomic organisation of the seven ParaHox genes of coelacanths Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells Sox9-haploinsufficiency causes glucose intolerance in mice A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths The genetics of type 2 diabetes.Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice.Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.A reconsideration of the origins of the type 2 diabetes epidemic among Native Americans and the implications for intervention policy.The insulin gene in diabetes.The search for type 2 diabetes susceptibility genes using whole-genome scans: an epidemiologist's perspective.Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice Genetic approaches to the molecular understanding of type 2 diabetes.Development and diseases of the pancreas.Pdx1 restores beta cell function in Irs2 knockout mice.Genetics of type 2 diabetes and insulin resistance: knowledge from human studies.Pancreatic Duodenal Homeobox (PDX-1) in health and disease.Glucotoxicity and beta-cell failure in type 2 diabetes mellitus.An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.

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Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

http://www.wikidata.org/entity/Q24562726

description

1999 nî lūn-bûn

@nan

1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Defective mutations in the ins ...... onset type 2 diabetes mellitus

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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type

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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prefLabel

Defective mutations in the ins ...... onset type 2 diabetes mellitus

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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Defective mutations in the ins ...... onset type 2 diabetes mellitus

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C Dina

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D A Stoffers

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J F Habener

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P2860

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

Insulin-promoter-factor 1 is required for pancreas development in mice

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.

Functional characterization of the transactivation properties of the PDX-1 homeodomain protein.

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus

An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians

Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs.

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10.1172/JCI7469

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9

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104

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Philippe Froguel

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24764789

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10545531

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type-2 diabetes

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409821

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