Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2
about
Janus kinases in immune cell signalingTyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activityAnalysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutationJak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptorMegakaryopoiesisMechanism of attenuation of leptin signaling under chronic ligand stimulation.STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutantThe molecular regulation of Janus kinase (JAK) activationJak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activationFERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphomaJanus kinase 3: the controller and the controlledCrystal Structure of the FERM-SH2 Module of Human Jak2.Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disordersJak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activityThe Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenesIdentification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activationHematopoietic cytokine receptor signaling.Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken.New insights into the structure and function of the pseudokinase domain in JAK2.Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling.Fos-Zippered GH Receptor Cytosolic Tails Act as Jak2 Substrates and Signal Transducers.Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm.A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin.Association of a genetic marker at the bovine Janus kinase 2 locus (JAK2/RsaI) with milk production traits of four cattle breeds.
P2860
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P2860
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2
description
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Oktober 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/10/18)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/10/18)
@nl
наукова стаття, опублікована в жовтні 2006
@uk
مقالة علمية (نشرت في 18-10-2006)
@ar
name
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@ast
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@en
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@nl
type
label
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@ast
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@en
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@nl
prefLabel
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@ast
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@en
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@nl
P2093
P2860
P3181
P356
P1433
P1476
Receptor specific downregulati ...... ion in the FERM domain of Jak2
@en
P2093
Evan Parganas
James N. Ihle
Megumi Funakoshi-Tago
Stephane Pelletier
Tadashi Matsuda
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601365
P407
P577
2006-10-18T00:00:00Z