Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6
about
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasisMurine mutants in the study of systemic iron metabolism and its disorders: an update on recent advancesThe role of TMPRSS6/matriptase-2 in iron regulation and anemiaBMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelinEffect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and RatsHepcidin and iron regulation, 10 years later.Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 proteinRole of matriptase-2 (TMPRSS6) in iron metabolism.Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasisMembrane-anchored serine proteases in vertebrate cell and developmental biologyMolecular mechanisms of hepcidin regulation: implications for the anemia of CKD.EPO-mediated reduction in Hamp expression in vivo corrects iron deficiency anaemia in TMPRSS6 deficiency.Effect of iron overload and iron deficiency on liver hemojuvelin proteinTmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or HfeUnraveling mechanisms regulating systemic iron homeostasis.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.The role of Matriptase-2 during the early postnatal development in humans.The liver: conductor of systemic iron balance.Molecular basis of iron-loading disorders.Iron-deficiency anemia secondary to mutations in genes controlling hepcidin.Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis.Iron storage disease in Asia-Pacific populations: the importance of non-HFE mutations.Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.New strategies to target iron metabolism for the treatment of beta thalassemiaThe liver in regulation of iron homeostasis.Hepcidin biology and therapeutic applications.Mössbauer Spectra of Mouse Hearts Reveal Age-dependent Changes in Mitochondrial and Ferritin Iron Levels.Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.What can we learn from ineffective erythropoiesis in thalassemia?A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction
P2860
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P2860
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6
description
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im November 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/11/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/11/01)
@nl
наукова стаття, опублікована в листопаді 2009
@uk
مقالة علمية (نشرت في نوفمبر 2009)
@ar
name
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@ast
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@en
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@nl
type
label
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@ast
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@en
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@nl
prefLabel
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@ast
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@en
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@nl
P2093
P1476
Suppression of the hepcidin-en ...... velin and matriptase-2/TMPRSS6
@en
P2093
Ernest Beutler
Hongfan Peng
Jaroslav Truksa
Pauline Lee
Terri Gelbart
P304
P356
10.1111/J.1365-2141.2009.07873.X
P407
P577
2009-11-01T00:00:00Z