Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction
about
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal heartsDifferential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeatsTrim24 targets endogenous p53 for degradationActivation of Notch-mediated protective signaling in the myocardiumCommon variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac deathHes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndromeHeyL regulates the number of TrkC neurons in dorsal root gangliaTranscription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload.Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochleaMyocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias.Brugada syndrome risk loci seem protective against atrial fibrillation.Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.Notch signaling plays a key role in cardiac cell differentiation.Nitric oxide synthase-3 promotes embryonic development of atrioventricular valvesVertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.bHLH-Orange Transcription Factors in Development and Cancer.Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factorsHairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in miceReduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice.Heart valve development: regulatory networks in development and diseaseEmerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern?Differential gene expressions in atrial and ventricular myocytes: insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies.Notch signaling in cardiac valve development and disease.Genetic and functional genomics approaches targeting the Notch pathway in cardiac development and congenital heart disease.Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice.Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling.Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice.Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification.
P2860
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P2860
Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction
description
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im September 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/09/03)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/09/03)
@nl
наукова стаття, опублікована у вересні 2004
@uk
مقالة علمية (نشرت في 3-9-2004)
@ar
name
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@ast
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@en
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@nl
type
label
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@ast
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@en
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@nl
prefLabel
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@ast
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@en
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@nl
P2093
P1433
P1476
Targeted disruption of hesr2 r ...... that lead to heart dysfunction
@en
P2093
Hirofumi Tomimatsu
Hiroki Kokubo
Makoto Nakazawa
Randy L. Johnson
Sachiko Miyagawa-Tomita
Yasumi Nakashima
Yumiko Saga
P304
P356
10.1161/01.RES.0000141136.85194.F0
P577
2004-09-03T00:00:00Z