The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation
about
Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functionsPhosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeletonSmall G proteins in the cardiovascular system: physiological and pathological aspectsC3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical DevelopmentThe Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogasterPhysical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domainAnaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cellsMonocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cellsC3G regulates the size of the cerebral cortex neural precursor populationC3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion.Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signalsCardiovascular and craniofacial defects in Crk-null miceTC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells.Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomicsRap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factorsDefective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.Cell biology of embryonic migration.Cdk5 regulates Rap1 activity.C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis.Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteinsThe ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells.C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction.Rap1 mutants with increased affinity for the guanine-nucleotide exchange factor C3G.Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells.Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells.Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease.How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma
P2860
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P2860
The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation
description
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Januar 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/01/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/01/01)
@nl
наукова стаття, опублікована в січні 2003
@uk
مقالة علمية (نشرت عام 2003)
@ar
name
The guanine nucleotide exchang ...... esions and vascular maturation
@ast
The guanine nucleotide exchang ...... esions and vascular maturation
@en
The guanine nucleotide exchang ...... esions and vascular maturation
@nl
type
label
The guanine nucleotide exchang ...... esions and vascular maturation
@ast
The guanine nucleotide exchang ...... esions and vascular maturation
@en
The guanine nucleotide exchang ...... esions and vascular maturation
@nl
prefLabel
The guanine nucleotide exchang ...... esions and vascular maturation
@ast
The guanine nucleotide exchang ...... esions and vascular maturation
@en
The guanine nucleotide exchang ...... esions and vascular maturation
@nl
P3181
P356
P1433
P1476
The guanine nucleotide exchang ...... esions and vascular maturation
@en
P2093
Peter Gruss
Tim Thomas
P304
P3181
P356
10.1242/DEV.00217
P407
P577
2003-01-01T00:00:00Z