The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
about
Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosisPinkbar is an epithelial-specific BAR domain protein that generates planar membrane structuresCDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASPInsulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's diseaseEnlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.Single dose of L-dopa makes extinction memories context-independent and prevents the return of fearPostsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neuronsThe serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling.BAI1 regulates spatial learning and synaptic plasticity in the hippocampusSevere learning deficits of IRSp53 mutant mice are caused by altered NMDA receptor dependent signal transduction.I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration.A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions.A non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA.Modulation of hippocampal neural plasticity by glucose-related signaling.Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioningProteomic analysis of postsynaptic density in Alzheimer's diseaseModulation of behavior by scaffolding proteins of the post-synaptic density.Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance.Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.Synaptic plasticity, a symphony in GEF.BAR domain competition during directional cellular migration.Dendritic spines: the locus of structural and functional plasticity.The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition.Proteomic Analysis of Postsynaptic Protein Complexes Underlying Neuronal Plasticity.The neuronal insulin receptor in its environment.Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densitiesCdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.Mechanisms of cellular protrusions branch out.IRSp53 accumulates at the postsynaptic density under excitatory conditions.Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression.Treatment during a vulnerable developmental period rescues a genetic epilepsy.Mtss1 promotes maturation and maintenance of cerebellar neurons via splice variant-specific effects.
P2860
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P2860
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
description
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2009
@ast
im April 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/04/03)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/04/03)
@nl
наукова стаття, опублікована у квітні 2009
@uk
name
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@ast
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@en
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@nl
type
label
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@ast
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@en
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@nl
prefLabel
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@ast
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@en
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@nl
P2093
P2860
P50
P921
P356
P1476
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
@en
P2093
Fabio Morellini
Hans-Jürgen Kreienkamp
Kerstin Berhörster
Luminita Stoenica
Martin Korte
Michael Kintscher
Michaela Schweizer
Sabrina Sieber
Sara Mantoani
Stefan Kindler
P2860
P304
P356
10.1074/JBC.M808425200
P407
P577
2009-04-03T00:00:00Z