Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production
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A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolismAdrenocortical Gap Junctions and Their FunctionsACTH Regulation of Adrenal SR-B1Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformationRoles of scavenger receptor BI and APO A-I in selective uptake of HDL cholesterol by adrenal cellsLipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteinsDramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibilityDelayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient miceInflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance?Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor unElevated triglyceride content diminishes the capacity of high density lipoprotein to deliver cholesteryl esters via the scavenger receptor class B type I (SR-BI).Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsisScavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cellsExpression of scavenger receptor class B type 1 (SR-BI) promotes microvillar channel formation and selective cholesteryl ester transport in a heterologous reconstituted system.The APOA1/C3/A4/A5 cluster and markers of allostatic load in the Boston Puerto Rican Health Study.Microarray expression profiling identifies genes with altered expression in HDL-deficient mice.Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology.Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol.Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency.Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response.Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.SR-BI and HDL cholesteryl ester metabolism.SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearanceLipid droplets and steroidogenic cells.LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function.Influence of PDZK1 on lipoprotein metabolism and atherosclerosis.HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile.High density lipoprotein protects against polymicrobe-induced sepsis in miceCholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.Disruption of cholesterol homeostasis by plant sterols.Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.Cholesterol as a potential target for castration-resistant prostate cancer.Steroidogenesis-adrenal cell signal transduction.The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain.Knockdown of scavenger receptor class B type I reduces prostate specific antigen secretion and viability of prostate cancer cells.A Chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradation.The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.The N-terminal globular domain and the first class A amphipathic helix of apolipoprotein A-I are important for lecithin:cholesterol acyltransferase activation and the maturation of high density lipoprotein in vivo.Mechanism of scavenger receptor class B type I-mediated selective uptake of cholesteryl esters from high density lipoprotein to adrenal cells.Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the low-density lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells.
P2860
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P2860
Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production
description
1996 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1996
@ast
im Juni 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/06/01)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/06/01)
@nl
наукова стаття, опублікована в червні 1996
@uk
научни чланак (објављен 1996/06/01)
@sr
name
Apolipoprotein A-I is required ...... mal adrenal steroid production
@ast
Apolipoprotein A-I is required ...... mal adrenal steroid production
@en
Apolipoprotein A-I is required ...... mal adrenal steroid production
@nl
type
label
Apolipoprotein A-I is required ...... mal adrenal steroid production
@ast
Apolipoprotein A-I is required ...... mal adrenal steroid production
@en
Apolipoprotein A-I is required ...... mal adrenal steroid production
@nl
prefLabel
Apolipoprotein A-I is required ...... mal adrenal steroid production
@ast
Apolipoprotein A-I is required ...... mal adrenal steroid production
@en
Apolipoprotein A-I is required ...... mal adrenal steroid production
@nl
P2093
P2860
P921
P3181
P356
P1476
Apolipoprotein A-I is required ...... mal adrenal steroid production
@en
P2093
A. S. Plump
D. L. Williams
J. L. Breslow
J. S. Partin
S. K. Erickson
P2860
P304
P3181
P356
10.1172/JCI118716
P407
P577
1996-06-01T00:00:00Z