Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence
about
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammalsNon-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.Deletion of Ku86 causes early onset of senescence in miceUnraveling the mechanism of BRCA2 in homologous recombinationGenetic steps of mammalian homologous repair with distinct mutagenic consequencesThe relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability.EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forksMutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomesVariants in the GH-IGF axis confer susceptibility to lung cancer.Defining a genotoxic profile with mouse embryonic stem cellsThe therapeutic ratio is preserved for radiotherapy or cisplatin treatment in BRCA2-mutated prostate cancersTrex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair.BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells.FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.Expression Quantitative Trait loci (QTL) in tumor adjacent normal breast tissue and breast tumor tissue.Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models.Restoration of CAPAN-1 cells with functional BRCA2 provides insight into the DNA repair activity of individuals who are heterozygous for BRCA2 mutations.Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2A mechanism for 1,4-Benzoquinone-induced genotoxicity.Functional assays for analysis of variants of uncertain significance in BRCA2.Chromosomal Rearrangements in Cancer: Detection and potential causal mechanisms.Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.Radiation enhances caspase 3 cleavage of Rad51 in BRCA2-defective cells.Ku80-deleted cells are defective at base excision repair.ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins.Mechanism of tandem duplication formation in BRCA1-mutant cells.Double Heterozygosity for BRCA1 Pathogenic Variant and BRCA2 Polymorphic Stop Codon K3326X: A Case Report in a Southern Italian Family.
P2860
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P2860
Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence
description
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im August 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/08/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/08/01)
@nl
наукова стаття, опублікована в серпні 1998
@uk
научни чланак (објављен 1998/08/01)
@sr
name
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@ast
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@en
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@nl
type
label
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@ast
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@en
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@nl
prefLabel
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@ast
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@en
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@nl
P2093
P3181
P1433
P1476
Cells deleted for Brca2 COOH t ...... ation and premature senescence
@en
P2093
P304
P3181
P407
P577
1998-08-01T00:00:00Z