SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor
about
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neuronsPathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.Mutations in SYNGAP1 in autosomal nonsyndromic mental retardationRole of Unc51.1 and its binding partners in CNS axon outgrowthThe role of neuronal complexes in human X-linked brain diseasesSYNGAP1: Mind the GapRapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.A role for calcium-permeable AMPA receptors in synaptic plasticity and learning.The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reactionGenetic aspects of autism spectrum disorders: insights from animal modelsExpansion of the RASopathiesNMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampusRequirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memoryEnhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilinSynGAP moves out of the core of the postsynaptic density upon depolarizationTargeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteinsThe SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.Prioritizing the development of mouse models for childhood brain disordersReduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of SchizophreniaEvolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behaviorReduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disordersDecrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function.Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arraysClustered gene expression changes flank targeted gene loci in knockout mice.Automated design of genomic Southern blot probesModulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathwayPDZ affinity chromatography: a general method for affinity purification of proteins based on PDZ domains and their ligands.Human RAS superfamily proteins and related GTPases.The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTPAnalysis of 31-year-old patient with SYNGAP1 gene defect points to importance of variants in broader splice regions and reveals developmental trajectory of SYNGAP1-associated phenotype: case report.Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.Tyrosine phosphoproteomics identifies both codrivers and cotargeting strategies for T790M-related EGFR-TKI resistance in non-small cell lung cancer.In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93A polygenic burden of rare disruptive mutations in schizophrenia.The genetic basis of non-syndromic intellectual disability: a reviewEndogenous siRNAs and noncoding RNA-derived small RNAs are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination trainingNeuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells.
P2860
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P2860
SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor
description
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im November 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/11/15)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/11/15)
@nl
наукова стаття, опублікована в листопаді 2002
@uk
مقالة علمية (نشرت في 15-11-2002)
@ar
name
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@ast
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@en
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@nl
type
label
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@ast
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@en
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@nl
prefLabel
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@ast
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@en
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@nl
P2093
P50
P921
P3181
P1476
SynGAP regulates ERK/MAPK sign ...... c density 95 and NMDA receptor
@en
P2093
Ayako M Watabe
Colin M O'Carroll
Douglas J C Strathdee
Holly J Carlisle
Jennifer Monti
Karen Porter
Noboru H Komiyama
Paul Charlesworth
Thomas J O'Dell
P304
P3181
P356
10.1523/JNEUROSCI.22-22-09721.2002
P407
P577
2002-11-15T00:00:00Z