The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.
about
Essential role of retinoblastoma protein in mammalian hair cell development and hearing.Quo vadis, hair cell regeneration?Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cellsTwists in views on RB functions in cellular signaling, metabolism and stem cellsThe quest for restoring hearing: Understanding ear development more completely.High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitorA historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?"Supernumerary human hair cells-signs of regeneration or impaired development? A field emission scanning electron microscopy studyMammalian Cochlear Hair Cell Regeneration and Ribbon Synapse ReformationAuditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing.Over half the hair cells in the mouse utricle first appear after birth, with significant numbers originating from early postnatal mitotic production in peripheral and striolar growth zonesIn vivo proliferative regeneration of balance hair cells in newborn mice.Stem cell therapy for the inner ear: recent advances and future directions.A review of gene delivery and stem cell based therapies for regenerating inner ear hair cellsRecent advances in hair cell regeneration research.Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure.The myc road to hearing restoration.Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Conditional and inducible gene recombineering in the mouse inner earNotch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.The challenge of hair cell regeneration.Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Filling the silent void: genetic therapies for hearing impairment.MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro.Transcriptomic analysis of the developing and adult mouse cochlear sensory epithelia.Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damageRegeneration of Hair Cells: Making Sense of All the Noise.Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs.Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells.Hair cell fate decisions in cochlear development and regenerationRegeneration of the mammalian inner ear sensory epitheliumIn vivo proliferation of postmitotic cochlear supporting cells by acute ablation of the retinoblastoma protein in neonatal miceSox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear.Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear.Emx2 and early hair cell development in the mouse inner ear.DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cellsRestrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression.Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift.Hair cell regeneration.Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context
P2860
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P2860
The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
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2005年の論文
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2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
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2005年学术文章
@zh-my
2005年学术文章
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2005年學術文章
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name
The retinoblastoma gene pathwa ...... r cells of the mouse inner ear
@nl
The retinoblastoma gene pathwa ...... cells of the mouse inner ear.
@ast
The retinoblastoma gene pathwa ...... cells of the mouse inner ear.
@en
type
label
The retinoblastoma gene pathwa ...... r cells of the mouse inner ear
@nl
The retinoblastoma gene pathwa ...... cells of the mouse inner ear.
@ast
The retinoblastoma gene pathwa ...... cells of the mouse inner ear.
@en
prefLabel
The retinoblastoma gene pathwa ...... r cells of the mouse inner ear
@nl
The retinoblastoma gene pathwa ...... cells of the mouse inner ear.
@ast
The retinoblastoma gene pathwa ...... cells of the mouse inner ear.
@en
P2093
P2860
P356
P1433
P1476
The retinoblastoma gene pathwa ...... cells of the mouse inner ear.
@en
P2093
Eldad Zacksenhaus
Johanna Mantela
Jukka Ylikoski
Ulla Pirvola
P2860
P304
P356
10.1242/DEV.01834
P407
P577
2005-04-20T00:00:00Z