Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells
about
Quo vadis, hair cell regeneration?Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma protein.Conditional gene expression in the mouse inner ear using Cre-loxP.Sensory hair cell development and regeneration: similarities and differencesWhere hearing starts: the development of the mammalian cochleaCell cycle reactivation of cochlear progenitor cells in neonatal FUCCI mice by a GSK3 small molecule inhibitor.Mitosis in neurons: Roughex and APC/C maintain cell cycle exit to prevent cytokinetic and axonal defects in Drosophila photoreceptor neuronsA historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?"Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivoAuditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing.In vivo proliferative regeneration of balance hair cells in newborn mice.Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma.Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.Gene-expression analysis of hair cell regeneration in the zebrafish lateral line.Recent advances in hair cell regeneration research.The myc road to hearing restoration.Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Disrupting the interaction between retinoblastoma protein and Raf-1 leads to defects in progenitor cell proliferation and survival during early inner ear development.The challenge of hair cell regeneration.Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Noise induced changes in the expression of p38/MAPK signaling proteins in the sensory epithelium of the inner ear.MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro.Regeneration of Hair Cells: Making Sense of All the Noise.Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs.Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells.Hair cell fate decisions in cochlear development and regenerationIn vivo proliferation of postmitotic cochlear supporting cells by acute ablation of the retinoblastoma protein in neonatal miceRestrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression.Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model.p27(Kip1) is required to maintain proliferative quiescence in the adult cochlea and pituitary.In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.Cell cycle regulation in hair cell development and regeneration in the mouse cochlea.Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.Hair cell progenitors: identification and regulatory genes.Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research.Regeneration of hair cells in the mammalian vestibular system.Development and regeneration of vestibular hair cells in mammals.Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?
P2860
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P2860
Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@ast
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@en
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@nl
type
label
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@ast
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@en
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@nl
prefLabel
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@ast
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@en
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@nl
P2093
P2860
P356
P1476
Rapid cell-cycle reentry and c ...... postnatal cochlear hair cells
@en
P2093
Marcus B Valentine
Mary K Corbett
Suzanne J Baker
P2860
P304
P356
10.1073/PNAS.0708061105
P407
P577
2008-01-04T00:00:00Z