Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
about
Structure-guided design of selective Epac1 and Epac2 agonistsThe RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membraneIn vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human isletsA direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosisGlucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cellsNoc2 is essential in normal regulation of exocytosis in endocrine and exocrine cellsEpac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cellMechanisms of action of glucagon-like peptide 1 in the pancreasRedundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter releaseβ-Cell glutamate signaling: Its role in incretin-induced insulin secretionCyclic AMP dynamics in the pancreatic β-cellEpac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.Cell physiology of cAMP sensor Epac.Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cellsFunctional characterization of N-terminally GFP-tagged GLP-1 receptorThe neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretionRap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferationNerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to EpacJNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked releasePiccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosisDistinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Direct spatial control of Epac1 by cyclic AMP.Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Establishment of new clonal pancreatic β-cell lines (MIN6-K) useful for study of incretin/cyclic adenosine monophosphate signalingCell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytesSphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretionRegulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling.PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.Small G proteins in islet beta-cell function.Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus.New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells.Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells.Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment.Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosisCell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.
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P2860
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
description
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Dezember 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/12/07)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/12/07)
@nl
наукова стаття, опублікована в грудні 2001
@uk
name
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@ast
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@en
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@nl
type
label
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@ast
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@en
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@nl
prefLabel
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@ast
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@en
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@nl
P2093
P2860
P356
P1476
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion
@en
P2093
M. Miyazaki
T. Shibasaki
Y. Kashima
P2860
P304
46046–46053
P356
10.1074/JBC.M108378200
P407
P577
2001-12-07T00:00:00Z