Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion
about
MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitusSorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cellsNuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cellsSynthesis and secretion of renin in mice with induced genetic mutationsThe F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.Structural genomics of protein phosphatasesX-ray structure of the mature ectodomain of phogrinICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATsSynergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesiclesRegulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagyThe dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning.A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis.The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.Immunologic and genetic factors in type 1 diabetes.Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2β, and GAD65.The effect of the MHC locus on autoantibodies in type 1 diabetesDeconstructing pancreas developmental biology.Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.Islet autoantigens: structure, function, localization, and regulation.Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease.Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2βIA-2 modulates dopamine secretion in PC12 cells.Neonatal β cell development in mice and humans is regulated by calcineurin/NFATCo-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brainProtein tyrosine phosphatases: functional inferences from mouse models and human diseases.Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growthSmall cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.Signaling from the secretory granule to the nucleus.Pathophysiologic changes in IA-2/IA-2β null mice are secondary to alterations in the secretion of hormones and neurotransmitters.The Ia-2β intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice.An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin.Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells.A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2beta).
P2860
Q21090997-2D6E1548-1976-4C61-881F-980BE2640C9EQ24297969-AB77BEEF-B429-44A8-8201-9DE3108D25BAQ24676036-EFB14044-AD93-4CA8-8514-C053F8674FA2Q26999938-5B81C606-D35B-4811-B28C-5EEBCA6C5D00Q27308703-5C15C9FB-E5D2-481B-9104-7D716CAA6B91Q27649211-BA987412-0529-411D-BC12-3856A5FEE207Q27696208-923EEFDD-5C15-4896-808D-19ABB4BEF1B9Q28115798-264BD79D-F5FA-4B0A-8F10-E9581DE9F322Q28117194-133283CE-A49E-4C7A-AF70-81D9955A7378Q28512746-C60F8913-D94A-44E5-B1DE-78D0E69BE2BDQ28586396-B1B52329-2F65-47AD-AD08-281935F06DA1Q30486711-21925EA5-A9C7-4D17-9F50-6F44AD6B93E0Q33426357-3F8CB9D6-8EC7-4122-BA84-DF695DEC1075Q33588721-E38A920D-5DC3-4121-9290-BAFBD4EEBBF1Q33684265-64A3D89C-04EE-44B3-8B38-9E52B75716DBQ33769952-A97CCBB8-DF7A-41A7-AF1D-CCD8A13FD745Q33853806-6FC3A46A-5979-4A4D-AF7D-42152B9201A8Q34304638-652FC232-5E24-49BD-BCE6-67313E706353Q34882557-0C31F778-6C3C-40D9-9B41-2A426D059FBBQ35684542-8C4836FB-0008-4CFD-9F80-B46EAC7044E5Q35726979-FCE71ED6-361A-490D-8C8B-0034DC5B4C5BQ36009271-90FFA4BD-4E73-44E3-88D3-98ED1B0C30CFQ36069404-82B7B2D9-1D9B-4A22-B480-90BFA54840B2Q36119378-30F342FE-AE3D-4CF5-9D4D-D9BEFEB99241Q36170039-70F68819-5C83-4461-91E2-282F92B9A2E5Q36309194-719240ED-EA5A-4724-9EED-81BA0D46808FQ36390368-1560BD09-BDFE-4AE9-854B-2C5CE1334ED7Q36655088-72B52CE1-03D6-48CF-9E49-535D97D7C394Q36898059-589FF2A3-17C0-4368-983B-37826A331114Q37094061-7EFD852B-BA93-4DCD-A407-E921A3828D29Q37100058-708AFA90-AEEA-46A6-986D-104F1E4248AFQ37105344-0DBF3539-85B2-4C81-B973-A359385B0A42Q37286761-913554AD-564E-4A24-BEAB-175A4E01ECE4Q37326967-99DE78E7-6BF9-4A33-9C7A-74397C4FB05FQ37577009-2394FE9B-4B76-42BA-9962-CC8ED0A7371DQ37592431-E6500FC1-018D-49E9-AFCF-7496AAD55C89Q38856816-DE174705-03D8-45EB-87C0-1800574F1807Q40424977-68909784-B6DB-439C-A62C-5CBAC26F3A5CQ40522071-C07C64D0-C746-4B72-A339-679143E27703Q40593923-4AADCA7C-C978-4734-839A-B0EC751DBF73
P2860
Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion
description
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Juni 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/06/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/06/01)
@nl
наукова стаття, опублікована в червні 2002
@uk
مقالة علمية (نشرت في يونيو 2002)
@ar
name
Targeted disruption of the pro ...... ce tests and insulin secretion
@ast
Targeted disruption of the pro ...... ce tests and insulin secretion
@en
Targeted disruption of the pro ...... ce tests and insulin secretion
@nl
type
label
Targeted disruption of the pro ...... ce tests and insulin secretion
@ast
Targeted disruption of the pro ...... ce tests and insulin secretion
@en
Targeted disruption of the pro ...... ce tests and insulin secretion
@nl
prefLabel
Targeted disruption of the pro ...... ce tests and insulin secretion
@ast
Targeted disruption of the pro ...... ce tests and insulin secretion
@en
Targeted disruption of the pro ...... ce tests and insulin secretion
@nl
P2093
P921
P3181
P1433
P1476
Targeted disruption of the pro ...... ce tests and insulin secretion
@en
P2093
Abner Louis Notkins
Atsutaka Kubosaki
Jingping Xie
Keiichi Saeki
Michael S. Lan
P304
P3181
P356
10.2337/DIABETES.51.6.1842
P407
P577
2002-06-01T00:00:00Z