Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT - Wikidata - awgldk - TriplyDB

Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

http://www.wikidata.org/entity/Q36655088

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Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells Inflammatory response in islet transplantation.Human pancreatic beta-like cells converted from fibroblasts.Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy.NFAT targets signaling molecules to gene promoters in pancreatic β-cells.An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.Transgenic Expression of a Single Transcription Factor Pdx1 Induces Transdifferentiation of Pancreatic Acinar Cells to Endocrine Cells in Adult Mice.The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases Targeting purinergic receptors in islet transplantation.Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.Inhibition of DYRK1A Stimulates Human β-Cell Proliferation Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.Gene regulatory networks governing pancreas development.Protein phosphatases in pancreatic islets.Tacrolimus in pancreas transplant: a focus on toxicity, diabetogenic effect and drug-drug interactions.Clinical implementation of islet transplantation: A current assessment.Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation.Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.Novel factors modulating human β-cell proliferation.Advances in β cell replacement and regeneration strategies for treating diabetes Pharmacogenetics of posttransplant diabetes mellitus.Prediabetes in Pediatric Recipients of Liver Transplant: Mechanism and Risk Factors.Genome-Wide Association Study of Dietary Pattern Scores.Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells.Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.Replication confers β cell immaturity.SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans.A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes

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P2860

Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

http://www.wikidata.org/entity/Q36655088

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2012 nî lūn-bûn

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2012年論文

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name

Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

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Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

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Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

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Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

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Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

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Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

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P356

J.DEVCEL.2012.05.014

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Developmental Cell

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Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

@en

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Gerald R Crabtree

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Rita Bottino

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Seung K Kim

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William R Goodyer

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Xueying Gu

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Yinghua Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation

Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells

ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs

Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

NFAT signaling: choreographing the social lives of cells

The calcineurin phosphatase complex modulates immunogenic B cell responses

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose

Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion

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21-34

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10.1016/J.DEVCEL.2012.05.014

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22814600

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