Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network
about
Wnt modulators in the biotech pipelineDact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrainPosterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streakAll Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinasesModulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects.The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways.Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesitySecreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.Expression analysis of Dact1 in mice using a LacZ reporter.miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling.Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.MiR-26a functions oppositely in osteogenic differentiation of BMSCs and ADSCs depending on distinct activation and roles of Wnt and BMP signaling pathway.Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.Lighting the fat furnace without SFRP5SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling.Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells.Olive leaf extract attenuates obesity in high-fat diet-fed mice by modulating the expression of molecules involved in adipogenesis and thermogenesis.Wnt signalling and the control of cellular metabolism.SIRT1 suppresses adipogenesis by activating Wnt/β-catenin signaling in vivo and in vitro.Downregulation of Sfrp5 promotes beta cell proliferation during obesity in the rat.Plasma Sfrp5 and adiponectin levels in relation to blood pressure among obese children.Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells.Inverse associations between serum levels of secreted frizzled-related protein-5 (SFRP5) and multiple cardiometabolic risk factors: KORA F4 study.Plasma Sfrp5 levels correlate with determinants of the metabolic syndrome in Chinese adults.Whole-transcriptome analysis of mouse adipose tissue in response to short-term caloric restriction.Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC.Comparison of adipocyte-specific gene expression from WNIN/Ob mutant obese rats, lean control, and parental control.Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-β signaling pathways during chicken limb development.Sfrp5 correlates with insulin resistance and oxidative stress.Sfrp5 associates with beta-cell function in humans.Cloning and Expression of SFRP5 in Tibetan Chicken and its Relationship with IMF Deposition.Nucleotide variation of sFRP5 gene is not associated with obesity in children and adolescents.
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P2860
Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network
description
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
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im März 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2009/03/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/03/01)
@nl
наукова стаття, опублікована в березні 2009
@uk
مقالة علمية (نشرت في مارس 2009)
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name
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@ast
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@en
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@nl
type
label
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@ast
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@en
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@nl
prefLabel
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@ast
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@en
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@nl
P2093
P2860
P3181
P356
P1433
P1476
Dact1, a nutritionally regulat ...... beta-catenin signaling network
@en
P2093
Antonio J. Vidal-Puig
Benjamin N. R. Cheyette
Chiara Franzin
Claire Lagathu
Constantinos Christodoulides
Edoardo Dalla Nora
Gema Medina-Gomez
Jaswinder K. Sethi
Mark Campbell
Sam Virtue
P2860
P304
P3181
P356
10.2337/DB08-1180
P407
P577
2009-03-01T00:00:00Z