Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation
about
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysisOncogenic function of DACT1 in colon cancer through the regulation of β-cateninWGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulationSfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signalingHDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencingDACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modificationsIdentification of novel rare mutations of DACT1 in human neural tube defectsDapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleusProtein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradationWnt/beta-catenin signaling and small molecule inhibitorsPDZ domains and their binding partners: structure, specificity, and modificationShared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signalingDishevelled nuclear shuttlingRegulation of actin cytoskeleton architecture by Eps8 and Abi1.Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated HepatocarcinogenesisDevelopment of anticancer agents targeting the Wnt/β-catenin signalingRegulation of TGF-β Signal TransductionRole of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunityDapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneuronsDirect binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of FrizzledSulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein DishevelledIdentification of transmembrane protein 88 (TMEM88) as a dishevelled-binding proteinDisruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signalingDact2 is expressed in the developing ureteric bud/collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cellsDact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling networkCasein kinase Iepsilon modulates the signaling specificities of dishevelledDact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrainPosterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streakLoss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in miceAll Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinasesDishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signalingRor2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerizationGpr125 modulates Dishevelled distribution and planar cell polarity signaling.Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes-Brocks SyndromeEpigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.Peripheral nerve morphogenesis induced by scaffold micropatterningMethylation of DACT2 promotes breast cancer development by activating Wnt signalingMature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss.Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.
P2860
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P2860
Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Dapper, a Dishevelled-associat ...... quired for notochord formation
@ast
Dapper, a Dishevelled-associat ...... quired for notochord formation
@en
Dapper, a Dishevelled-associat ...... quired for notochord formation
@nl
type
label
Dapper, a Dishevelled-associat ...... quired for notochord formation
@ast
Dapper, a Dishevelled-associat ...... quired for notochord formation
@en
Dapper, a Dishevelled-associat ...... quired for notochord formation
@nl
prefLabel
Dapper, a Dishevelled-associat ...... quired for notochord formation
@ast
Dapper, a Dishevelled-associat ...... quired for notochord formation
@en
Dapper, a Dishevelled-associat ...... quired for notochord formation
@nl
P2093
P3181
P1433
P1476
Dapper, a Dishevelled-associat ...... quired for notochord formation
@en
P2093
Benjamin N R Cheyette
Eric P Fox
Jeffrey R Miller
Joshua S Waxman
Ken-Ichi Takemaru
Laird C Sheldahl
Natasha Khlebtsova
Thomas Earnest
P304
P3181
P356
10.1016/S1534-5807(02)00140-5
P407
P577
2002-04-01T00:00:00Z