The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice
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Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membraneNovel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutationsZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in uterottm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasisStructure, function, and regulation of a subfamily of mouse zinc transporter genesZip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cellsIdentification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testisThe adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.Behavioral impairments in animal models for zinc deficiency.The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency.Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation.Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc StatusTissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4Generation and characterization of mice lacking the zinc uptake transporter ZIP3.MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters.A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integritySlc39a7/zip7 plays a critical role in development and zinc homeostasis in zebrafish.Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis.A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein.Cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium.The relevance of the colon to zinc nutrition.The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicityA modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegansExtreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa.Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zincZip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells.Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.Infantile zinc deficiency: association with autism spectrum disorders.Zinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activationHomeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation.Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells.Intestinal and placental zinc transport pathways.Regulation of zinc-responsive Slc39a5 (Zip5) translation is mediated by conserved elements in the 3'-untranslated regionThe Zinc Concentration in the Diet and the Length of the Feeding Period Affect the Methylation Status of the ZIP4 Zinc Transporter Gene in Piglets.
P2860
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P2860
The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice
description
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im August 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/08/29)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/08/29)
@nl
наукова стаття, опублікована в серпні 2003
@uk
name
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@ast
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@en
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@nl
type
label
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@ast
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@en
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@nl
prefLabel
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@ast
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@en
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@nl
P2093
P3181
P356
P1476
The acrodermatitis enteropathi ...... lated zinc transporter in mice
@en
P2093
David Eide
Glen K. Andrews
Jane Gitschier
Jodi Dufner-Beattie
Yien-Ming Kuo
P304
33474–33481
P3181
P356
10.1074/JBC.M305000200
P407
P577
2003-08-29T00:00:00Z